Volume 6, Number 1 (Vol.6 No.1 Oct 2017)                   rbmb.net 2017, 6(1): 39-49 | Back to browse issues page


XML Print


Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:

Keyfi F, Lukacs Z, Varasteh A. A Description of Reference Ranges for Organic Acids in Urine Samples from A Pediatric Population in Iran. rbmb.net. 2017; 6 (1) :39-49
URL: http://rbmb.net/article-1-150-en.html

Immunobiochemistry Lab, Allergy Research Center, Mashhad University of Medical Sciences, Mashhad, Iran - Varastegan Institute for Medical Sciences, Mashhad, Iran - Pardis Clinical and Genetic Laboratory, Mashhad, Iran.
Abstract:   (1286 Views)

Background: Organic acids refer to a family of compounds that are intermediates in a variety of metabolic pathways. Many organic acids are present in urine from clinically normal individuals. Elevated levels of urine organic acids cause to the organic acidurias, disorders in which some metabolic pathways in organic acid metabolism are blocked. The present work identified major and minor urinary acidic metabolites in normal subjects, and their quantitative ranges in a pediatric population of Iran.

Methods: Two hundred and fifty-one healthy subjects, including 132 males and 119 females, from 2 days to 15 years of age were enrolled. Urinary organic acids were extracted from urine with organic solvents and identified and quantified by gas chromatography-mass spectrometry.

Results: The results provide a foundation on which to check results for patients with potentially abnormal organic acidurias. By this method 98 organic acids were identified in a pediatric population of Iran.

Conclusions: The present work identifies and quantifies major and minor urinary metabolites excreted by normal subjects. We also analyzed urine from 30 patients with organic acid metabolism abnormalities and compared the concentrations of specific organic acids with those from urines of normal individuals.

Full-Text [PDF 659 kb]   (587 Downloads)    
Type of Article: Original Article | Subject: Special
Received: 2017/03/15 | Accepted: 2017/03/15 | Published: 2017/03/15

Add your comments about this article : Your username or email:
Write the security code in the box

Send email to the article author


© 2015 All Rights Reserved | Reports of Biochemistry and Molecular Biology

Designed & Developed by : Yektaweb