Volume 5, Issue 2 (Vol.5 No.1 Apr 2017)                   rbmb.net 2017, 5(2): 83-90 | Back to browse issues page

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Mahmoudian R A, Abbaszadegan M R, Forghanifard M M, Moghbeli M, Moghbeli F, Chamani J et al . Biological and Clinicopathological Significance of Cripto-1 Expression in the Progression of Human ESCC. rbmb.net. 2017; 5 (2) :83-90
URL: http://rbmb.net/article-1-106-en.html
Faculty of Sciences, Department of Biochemistry and Biophysics, Mashhad Branch, Islamic Azad University, Mashhad, Iran.
Abstract:   (7859 Views)

Background: Human Cripto-1, a member of the EGF-CFC family, is involved in embryonic development, embryonic stem cell maintenance, and tumor progression. It also participates in multiple cell signaling pathways including Wnt, Notch, and TGF-β. Remarkably, it is expressed in cancer stem cell (CSC) compartments, boosting tumor cell migration, invasion, and angiogenesis. Although Cripto-1 is overexpressed in a variety of human malignant tumors, its expression in esophageal squamous cell carcinoma (ESCC) remains unclear. Our aim in this study was to evaluate the possible oncogenic role of Cripto-1 in ESCC progression and elucidate its association with clinicopathological parameters in patients.

Methods: In this study, Cripto-1 expression in 50 ESCC tissue samples was analyzed and compared to corresponding margin-normal esophageal tissues using quantitative real-time PCR.

Results: Cripto-1 was overexpressed in nearly 40% of ESCC samples compared with normal tissue samples. Significant correlations were observed between Cripto-1 expression and tumor differentiation grade, progression stage, and location (p < 0.05).

Conclusions: Our results indicate that overexpression of Cripto-1 is involved in the development of ESCC. Further assessment will be necessary to determine the role of Cripto-1 cross talk in ESCC tumorigenesis.  

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Type of Article: Original Article | Subject: Cell Biology
Received: 2016/07/31 | Accepted: 2016/08/20 | Published: 2017/04/30

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