Volume 3, Issue 2 (Vol.3 No.2 Apr 2015)                   rbmb.net 2015, 3(2): 62-67 | Back to browse issues page

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Samadi Noshahr Z, Shahraki M R, Ahmadvand H, Nourabadi D, Nakhaei A. Protective Effects of Withania somnifera Root on Inflammatory Markers and Insulin Resistance in Fructose-Fed Rats. rbmb.net. 2015; 3 (2) :62-67
URL: http://rbmb.net/article-1-60-en.html
Department of Biochemistry, Faculty of Medicine, Lorestan University of Medical Sciences, Khorram Abad, Iran
Abstract:   (2722 Views)

Background: We investigated the effects of Withania somnifera root (WS) on insulin resistance, tumor necrosis factor α (TNF-α), and interleukin-6 (IL-6) in fructose-fed rats.

Methods: Forty-eight Wistar-Albino male rats were randomly divided into four groups (n=12); Group I as control, Group II as sham-treated with WS by 62.5mg/g per diet, Group III fructose-fed rats received 10%W/V fructose, and Group IV fructose- and WS-fed rats. After eight weeks blood samples were collected to measure glucose, insulin, IL-6, and TNF-α levels in sera.

Results: Blood glucose, insulin, homeostasis model assessment for insulin resistance (HOMA-R), IL-6, and TNF-α levels were all significantly greater in the fructose-fed rats than in the controls. Treatment with WS significantly (P < 0.05) inhibited the fructose-induced increases in glucose, insulin, HOMA-R, IL-6, and TNF-α.

Conclusion: Our data suggest that WS normalizes hyperglycemia in fructose-fed rats by reducing inflammatory markers and improving insulin sensitivity.

Full-Text [PDF 465 kb]   (554 Downloads)    
Subject: Cell Biology
Received: 2016/08/21 | Accepted: 2016/08/21 | Published: 2016/08/21

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