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Kian A, Parkhideh S, Ghaffari Nazari H, Nikoonezhad M, Jalili A, Shahsavan S et al . Pre Transplantation Serum Parathyroid Hormone Influences the Number of Mobilized CD34 + Hematopoietic Stem Cells in Autologous Hematopoietic Stem Cell Transplantation. rbmb.net 2021; 10 (1) :76-83
URL: http://rbmb.net/article-1-607-en.html
Pre Transplantation Serum Parathyroid Hormone Influences the Number of Mobilized CD34 + Hematopoietic Stem Cells in Autologous Hematopoietic Stem Cell Transplantation
Abdolhamed Kian , Sayeh Parkhideh * , Haniyeh Ghaffari Nazari , Maryam Nikoonezhad , Arsalan Jalili , Shaghayegh Shahsavan , Abbas Hajifathali
Hematopoietic Stem Cell Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Abstract:   (2484 Views)
Background: Parathyroid hormone (PTH) is a calcium homeostasis regulator and can affect bone marrow niche. PTH leads to the bone marrow stem cell niche expansion as well as the induction of stem cell mobilization from the bone marrow into peripheral blood. In this study, we evaluated the association between pre- transplantation serum PTH levels and the number of circulating CD34+ cells along with the platelets/white blood cells (Plt/WBC) engraftment in patients who underwent autologous Hematopoietic Stem Cell Transplantation .

Methods: Subjects for the study were 100 patients who received autologous hematopoietic stem cell transplantation (auto-HSCT), retrospectively. Serum levels of PTH, calcium, phosphorus, and alkaline phosphatase were measured before mobilization. Their impacts were measured on the number of mobilized CD34+ hematopoietic stem cells, and Plt/WBC engraftment.

Results: High levels of serum PTH (> 63.10 pg/mL) was significantly associated with higher number of CD34+ cells in peripheral blood after granulocyte- colony stimulating factor (G-CSF)-induced mobilization (p= 0.079*). Serum calcium at low levels were associated with higher number of circulating CD34+ cells post mobilization. Pre- transplantation serum levels of phosphorus and alkaline phosphatase on CD34+ numbers were not statistically significant. Serum Plt/WBC engraftment was not improved in presence of high levels of serum PTH.

Conclusions: We suggested that serum PTH levels before transplantation could be influential in raising the number of circulating CD34+ hematopoietic stem cell after mobilization.
Keywords: Auto-HSCT, CD34+ Cell, Pre- transplant PTH.
Full-Text [PDF 261 kb]   (1315 Downloads)    
Type of Article: Original Article | Subject: Biochemistry
Received: 2020/11/15 | Accepted: 2020/11/23 | Published: 2021/05/9
References
1. Hatzimichael E, Tuthill M. Hematopoietic stem cell transplantation. Stem cells cloning. 2010;3:105-17. [DOI:10.2147/SCCAA.S6815] [PMID] [PMCID]
2. Vellenga E, Van Agthoven M, Croockewit AJ, Verdonck LF, Wijermans PJ, van Oers MH, et al. Autologous peripheral blood stem cell transplantation in patients with relapsed lymphoma results in accelerated haematopoietic reconstitution, improved quality of life and cost reduction compared with bone marrow transplantation: the Hovon 22 study. Br J Haematol. 2001;114(2):319-26. [DOI:10.1046/j.1365-2141.2001.02926.x] [PMID]
3. Pecora AL. Impact of stem cell dose on hematopoietic recovery in autologous blood stem cell recipients. Bone Marrow Transplant. 1999;23(Suppl 2):S7-12. [DOI:10.1038/sj.bmt.1701668] [PMID]
4. Hopman RK, DiPersio JF. Advances in stem cell mobilization. Blood Rev. 2014;28(1):31-40. [DOI:10.1016/j.blre.2014.01.001] [PMID] [PMCID]
5. To LB, Levesque JP, Herbert KE. How I treat patients who mobilize hematopoietic stem cells poorly. Blood. 2011;118(17):4530-40. [DOI:10.1182/blood-2011-06-318220] [PMID]
6. Ballen K. Targeting the stem cell niche: squeezing blood from bones. Bone Marrow Transplant. 2007;39(11):655-60. [DOI:10.1038/sj.bmt.1705651] [PMID]
7. Ohishi M, Schipani E. PTH and stem cells. J Endocrinol Invest 2011;34(7):552-6.
8. Huber BC, Grabmaier U, Brunner S. Impact of parathyroid hormone on bone marrow-derived stem cell mobilization and migration. World J Stem Cells. 2014;6(5):637-643. [DOI:10.4252/wjsc.v6.i5.637] [PMID] [PMCID]
9. Parkhideh S, Chegeni R, Mehdizadeh M, Roshandel E, Tavakoli F, Hajifathali A. Effects of ABO incompatibility on the outcome of allogeneic hematopoietic stem cell transplantation. Transfus Apher Sci. 2020;59(2):102696. [DOI:10.1016/j.transci.2019.102696] [PMID]
10. Appelbaum FR, Forman SJ, Negrin RS, Blume KG. Thomas' hematopoietic cell transplantation: John Wiley & Sons;2011.
11. Perez-Simon JA, Diez-Campelo Ma, Martino R, Sureda A, Caballero D, Canizo C, et al. Impact of CD34+ cell dose on the outcome of patients undergoing reduced-intensity-conditioning allogeneic peripheral blood stem cell transplantation. Blood. 2003;102(3):1108-13. [DOI:10.1182/blood-2002-11-3503] [PMID]
12. Calvi L, Adams G, Weibrecht K, Weber JM, Olson DP, Knight MC, et al. Osteoblastic cells regulate the haematopoietic stem cell niche. Nature. 2003;425(6960):841-6. [DOI:10.1038/nature02040] [PMID]
13. Brunner S, Zaruba M-M, Huber B, David R, Vallaster M, Assmann G, et al. Parathyroid hormone effectively induces mobilization of progenitor cells without depletion of bone marrow. Exp hematol. 2008;36(9):1157-66. [DOI:10.1016/j.exphem.2008.03.014] [PMID]
14. Pirih FQ, Michalski MN, Cho SW, Koh AJ, Berry JE, Ghaname E, et al. Parathyroid hormone mediates hematopoietic cell expansion through interleukin-6. PloS one. 2010;5(10):e13657. [DOI:10.1371/journal.pone.0013657] [PMID] [PMCID]
15. Li JY, Adams J, Calvi LM, Lane TF, DiPaolo R, Weitzmann MN, et al. PTH expands short-term murine hemopoietic stem cells through T cells. Blood. 2012;120(22):4352-62. [DOI:10.1182/blood-2012-06-438531] [PMID] [PMCID]
16. Lomonte C, Derosa C, Vernaglione L, Casucci F, Losurdo N, Libutti P, et al. Serum parathyroid hormone and phosphate influence the levels of circulating CD34+ cells in uremia. J Nephrol. 2010;23(6):693-8.
17. Coppolino G, Bolignano D, De Paola L, Giulino C, Mannella A, Riccio M, et al. Parathyroid hormone and mobilization of circulating bone marrow-derived cells in uremic patients. J Investig Med. 2011;59(5):823-8. [DOI:10.2310/JIM.0b013e318214edf8] [PMID]
18. Ballen KK, Shpall EJ, Avigan D, Yeap BY, Fisher DC, McDermott K, et al. Phase I trial of parathyroid hormone to facilitate stem cell mobilization. Biol Blood Marrow Transplant. 2007;13(7):838-43. [DOI:10.1016/j.bbmt.2007.03.007] [PMID]
19. Adams GB, Martin RP, Alley IR, Chabner KT, Cohen KS, Calvi LM, et al. Therapeutic targeting of a stem cell niche. Nat Biotech. 2007;25(2):238-43. [DOI:10.1038/nbt1281] [PMID]
20. Brunner S, Theiss HD, Murr A, Negele T, Franz W-M. Primary hyperparathyroidism is associated with increased circulating bone marrow-derived progenitor cells. Am J Physiol Endocrinol Metab. 2007;293(6):E1670-5. [DOI:10.1152/ajpendo.00287.2007] [PMID]
21. Ballen K, Mendizabal AM, Cutler C, Politikos I, Jamieson K, Shpall EJ, et al. Phase II trial of parathyroid hormone after double umbilical cord blood transplantation. Biol Blood Marrow Transplant. 2012;18(12):1851-8. [DOI:10.1016/j.bbmt.2012.06.016] [PMID] [PMCID]
22. Asgharian-Rezaee M, Alipour-Farmad R, Tayarani-Najaran Z. Comparison of Osteogenic Potential of Phenytoin with Dexamethasone in Cultured Dental Pulp Stem Cells. Rep Biochem Mol Biol. 2020;9(3):331-337. [DOI:10.29252/rbmb.9.3.331] [PMID] [PMCID]
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