%0 Journal Article %A Ghanem, Heba Bassiony %A Emam, Marwa Nagy %A Ali, Dareen Abdelaziz Mohammed %A Abd-Ellatif, Rania Nagi %T Impact of Berberine on Some Epigenetic, Transcription Regulation and Inflammatory Biomarkers in a Mice Model of Epilepsy %J Reports of Biochemistry and Molecular Biology %V 10 %N 3 %U http://rbmb.net/article-1-660-en.html %R 10.52547/rbmb.10.3.362 %D 2021 %K Berberine, Epigenetics, Epilepsy, Transcription regulation & inflammatory biomarkers., %X Background: Epilepsy is one of the most widespread neurological disease worldwide. Status epilepticus (SE) is a life-threatening neurologic disorder. Neuroprotective approaches are increasingly to discover a promising therapy to manage epileptic disorders. This study aimed to assess the impact of berberine on some epigenetic, transcription regulation & inflammatory biomarkers in a mice model of epilepsy. Methods: This work was performed on; Group I: (control), Group II: berberine‐treated control, Group III: epilepsy group, Group IV: berberine‐treated epilepsy. Groups were subjected to assessment of Tumor growth factor-1ꞵ (TGF-1ꞵ), hypoxia inducible factor-1α (HIF-1α), brain derived neurotrophic factor (BDNF) levels, histone deacetylase (HDAC) activity & neuronal restrictive silencing factor (NRSF) gene expression. Results: Study showed significant increase in levels of HIF-1α, TGF-1β, HDAC activity & NRSF gene expression in epilepsy group & decrease in these levels in berberine treated epilepsy group. Significant decrease in BDNF levels in epilepsy & elevation in them in berberine treated epilepsy group. Conclusions: Our study showed the anti-epileptic impact of berberine via its regulatory effect on some epigenetic, transcription factors & inflammatory biomarkers in a mice model of epilepsy. %> http://rbmb.net/article-1-660-en.pdf %P 362-372 %& 362 %! Berberine impact on Biomarkers in Epilepsy a Mice %9 Original Article %L A-10-703-1 %+ Clinical laboratory sciences Department, College of Applied Medical Sciences, Jouf University, Sakaka, Saudi Arabia & Medical Biochemistry Department, Faculty of Medicine, Tanta University, Tanta, Egypt. %G eng %@ 2322-3480 %[ 2021