%0 Journal Article %A Karimkhani, Sara %A Chaleshi, Vahid %A Balaii, Hedie %A Tarban, Peyman %A Nourian, Mahyar %A Irani, Shiva %A Shahrokh, Shabnam %A Asadzadeh Aghdaei, Hamid %A Mohammad Alizadeh, Amir Houshang %A Norouzinia, Mohsen %A Zali, Mohammad Reza %T Lack of Association between Interleukin 23R (IL-23R) rs10889677 Polymorphism and Inflammatory Bowel Disease Susceptibility In an Iranian Population %J Reports of Biochemistry and Molecular Biology %V 7 %N 1 %U http://rbmb.net/article-1-169-en.html %R %D 2018 %K Crohn’s disease, Inflammatory bowel diseases, Interleukin 23 receptor, rs10889677, Ulcerative colitis, %X Background: Inflammatory bowel diseases (IBDs), which include ulcerative colitis (UC) and Crohn’s disease (CD), are inflammatory disorders that affect the gastrointestinal tract. A combination of inflammatory cytokines has an important role in IBD development. Genome-wide association studies have shown that polymorphisms in the interleukin-23R gene (IL-23R) increase susceptibility to IBD. The aim of this study was to investigate the IL-23R 3' UTR SNP to determine a potential association between genotype distribution and IBD. Methods: The case group included 102 IBD patients and the control group included 107 healthy individuals. IL-23R polymorphisms rs10889677 were genotyped using PCR-RFLP analysis. RFLP results were confirmed by direct sequencing. Results: The allele and genotype frequencies in patients and controls were evaluated and compared, and no significant association between this functional rs10889677 polymorphism and risk of IBD was observed (P=0.587; adjusted OR: 0.89; 95% CI: 0.597-1.339). We also found no significant association between CD (14.71%) and UC (85.29%) patients in allele or genotype levels (P>0.05). Conclusions: Our results suggest that the rs10889677 A>C polymorphism is not a potential prognostic marker in Iranian patients with IBD. %> http://rbmb.net/article-1-169-en.pdf %P 16-22 %& 16 %! Interleukin 23R polymorphism in inflammatory bowel diseases %9 Original Article %L A-10-94-1 %+ Gastroenterology and Liver Diseases Research Center, Research Institute for Gastroenterology and Liver Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran. %G eng %@ 2322-3480 %[ 2018