Reports of Biochemistry and Molecular Biology
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Basic Sciences
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admin
2322-3480
2322-3480
10.61186/rbmb
en
jalali
1398
4
1
gregorian
2019
7
1
8
2
online
1
fulltext
en
<em>Beta-Secretase 1 (BACE1)</em> Is Down-Regulated in Invasive Ductal Carcinoma of Breast
زیست شناسی ملکولی
Molecular Biology
مقالات اصلی
Original Article
<div style="text-align: justify;"><strong><em>Background:</em></strong> The enzyme beta-secretase 1 (BACE1) and its antisense transcript (<em>BACE1-AS</em>) have been implicated in the pathogenesis of Alzheimer's disease. Moreover, several lines of evidence point to their contribution in tumorigenesis.<br>
<br>
<strong><em>Methods:</em></strong> In the present study, we evaluated expression of BACE1 mRNA (<em>BACE1)</em> and <em>BACE1-AS</em> in 54 breast cancer tissues and 54 adjacent non-cancerous tissues (ANCTs) from the same patients using quantitative real-time PCR.<br>
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<strong><em>Results:</em></strong> <em>BACE1</em> was significantly down-regulated in tumoral tissues compared with ANCTs, while <em>BACE1-AS</em> expression was not significantly different between tumoral tissues and ANCTs. The Bayesian Multilevel model showed a significant difference in <em>BACE1</em> expression between stage 1 and 2 cancers after age-effect adjustments. <em>BACE1-AS</em> expression was significantly greater in ER-positive than in ER-negative samples (P=0.01). <em>BACE1</em> and <em>BACE1-AS</em> expression were not correlated with patient ages in any sample sets.<br>
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<strong><em>Conclusions:</em></strong> Significant correlations were detected between expression of these genes in both tumoral tissues and ANCTs. The current study provides evidence for differential <em>BACE1 </em>expression in breast tissues and suggests further assessment of the role of <em>BACE1</em> in the pathogenesis of cancer.<br>
</div>
BACE1, BACE1-AS, Breast Cancer, Lncrna.
200
207
http://rbmb.net/browse.php?a_code=A-10-187-5&slc_lang=en&sid=1
Hajar
Yaghoobi
hajar_yaghobi@yahoo.com
10031947532846006664
10031947532846006664
No
University of Medical Sciences, Shahrekord, Iran. & Department of Medical Biotechnology, School of Advanced Technologies, Shahrekord University of Medical Sciences, Shahrekord, Iran.
Hakim
Azizi
hakimazizi190@yahoo.com
10031947532846006665
10031947532846006665
No
Department of Medical Parasitology, School of Medicine, Zabol University of Medical Sciences, Zabol, Iran.
Mehdi
Banitalebi-Dehkordi
banitalebi@yahoo.com
10031947532846006666
10031947532846006666
No
University of Medical Sciences, Shahrekord, Iran.
Fatemeh
Mohammad Rezaei
f_m.rezaei@yahoo.com
10031947532846006667
10031947532846006667
No
Department of Medical Genetic, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran.
Shahram
Arsang-Jnag
shahramarsang@gmail.com
10031947532846006668
10031947532846006668
No
Clinical Research Development Center (CRDU), Qom University of Medical Sciences, Qom, Iran.
Mohammad
Taheri
mohammad_823@yahoo.com
10031947532846006669
10031947532846006669
Yes
Urogenital Stem Cell Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Soudeh
Ghafouri-Fard
s.ghafourifard@sbmu.ac.ir
10031947532846006670
10031947532846006670
No
Department of Medical Genetics, Shahid Beheshti University of Medical Sciences, Tehran, Iran.