Reports of Biochemistry and Molecular Biology
rbmb.net
Basic Sciences
http://rbmb.net
1
admin
2322-3480
2322-3480
10.61186/rbmb
en
jalali
1401
8
1
gregorian
2022
11
1
11
3
online
1
fulltext
en
Comparative Study of New Biomarkers in Iraqi DM2 with and without Complications
بیوشیمی
Biochemistry
مقالات اصلی
Original Article
<div style="text-align: justify;"><span style="text-justify:kashida"><span style="text-kashida:0%"><span style="line-height:normal"><span style="tab-stops:396.55pt"><b><i><span lang="EN-CA" style="font-size:12.0pt"><span new="" roman="" style="font-family:" times=""><span style="color:black">Background:</span></span></span></i></b> <span style="font-size:12.0pt"><span new="" roman="" style="font-family:" times=""><span style="color:black">Recent research indicates that persistent inflammatory responses may contribute to the rise of diabetic nephropathy (DN) and diabetic cardiovascular disease (DCVD) in type 2 diabetes mellitus patients (DM2). Numerous molecules associated with inflammation and angiogenesis have been implicated in the development and progression of DN and DCVD, respectively.</span></span></span></span></span></span></span><br>
<br>
<span style="text-justify:kashida"><span style="text-kashida:0%"><span style="line-height:normal"><span style="tab-stops:396.55pt"><b><i><span lang="EN-CA" style="font-size:12.0pt"><span new="" roman="" style="font-family:" times=""><span style="color:black">Methods:</span></span></span></i></b> <span style="font-size:12.0pt"><span new="" roman="" style="font-family:" times=""><span style="color:black">The subjects were separated into five groups: healthy controls (n= 25), type 2 diabetes mellitus patients (n= 30), type 2 diabetes mellitus patients with nephropathy DN (n= 30), and type 2 diabetes mellitus patients with cardiovascular disease DCVD (n= 30). The blood levels of irisin, IL-8, HbA1C, urea, and creatinine were determined.</span></span></span></span></span></span></span><br>
<br>
<span style="text-justify:kashida"><span style="text-kashida:0%"><span style="line-height:normal"><span style="tab-stops:396.55pt"><b><i><span lang="EN-CA" style="font-size:12.0pt"><span new="" roman="" style="font-family:" times=""><span style="color:black">Results:</span></span></span></i></b> <span style="font-size:12.0pt"><span new="" roman="" style="font-family:" times=""><span style="color:black">In current study there was high significant increased irisin levels (p< 0.001) in DN patients than other groups and a high significant decreased IL-8 level in DCVD.</span></span></span></span></span></span></span><br>
<br>
<span style="text-justify:kashida"><span style="text-kashida:0%"><span style="line-height:normal"><span style="tab-stops:396.55pt"><b><i><span lang="EN-CA" style="font-size:12.0pt"><span new="" roman="" style="font-family:" times=""><span style="color:black">Conclusions:</span></span></span></i></b> <span style="font-size:12.0pt"><span new="" roman="" style="font-family:" times=""><span style="color:black">Serum IL-8 and irisin levels may serve as early indicators of DM2 problems (DN, DCVD).</span></span></span></span></span></span></span></div>
DM2, DN, DCVD, HbA1C, IL-8, Irisin
400
404
http://rbmb.net/browse.php?a_code=A-10-978-1&slc_lang=en&sid=1
Husam
Salman Jasim
husam_alaythawy78@yahoo.com
100319475328460013677
100319475328460013677
Yes
Department of Chemistry, Ibn Al-Haitham, University of Baghdad, Baghdad 61023, Iraq
Anwar
Farooq Altaie
100319475328460013678
100319475328460013678
No
Department of Chemistry, Ibn Al-Haitham, University of Baghdad, Baghdad 61023, Iraq
Warkaa
Touma Saloum
100319475328460013679
100319475328460013679
No
Department of Chemistry, Ibn Al-Haitham, University of Baghdad, Baghdad 61023, Iraq
Ali
Hussein Ali
100319475328460013680
100319475328460013680
No
Ibn-Albalady Hospital for children and maternity Iraq