Reports of Biochemistry and Molecular Biology
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2022
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Intrauterine Instillation of Human Chorionic Gonadotropin with Intrauterine Insemination Catheter Around the Golden Time of Embryo Transfer Does Not Improve In Vitro Fertilization /Intracytoplasmic Sperm Injection Outcomes in Infertile Women: A Randomized Controlled Trial
بیوشیمی
Biochemistry
مقالات اصلی
Original Article
<div style="text-align: justify;"><span style="font-size:12pt"><span style="font-family:TimesNewRomanPS-BoldItalicMT"><span style="color:#000000"><span style="font-weight:bold"><span style="font-style:italic">Background: </span></span></span></span></span><span style="font-size:12pt"><span style="font-family:Times New Roman"><span style="color:#000000">We set out to explore the effect of intrauterine human chorionic gonadotropin (hCG) </span></span></span><span style="font-size:12pt"><span style="font-family:Times New Roman"><span style="color:#000000">instillation by intrauterine insemination (IUI) catheter before embryo transfer (ET) on assisted </span></span></span><span style="font-size:12pt"><span style="font-family:Times New Roman"><span style="color:#000000">reproductive technologies (ART) outcomes of infertile women.</span></span></span><br>
</div>
<div style="text-align: justify;"><span style="font-size:12pt"><span style="font-family:TimesNewRomanPS-BoldItalicMT"><span style="color:#000000"><span style="font-weight:bold"><span style="font-style:italic">Methods: </span></span></span></span></span><span style="font-size:12pt"><span style="font-family:Times New Roman"><span style="color:#000000">One hundred women with infertility who were scheduled for </span></span></span><span style="font-size:12pt"><span style="font-family:TimesNewRomanPS-ItalicMT"><span style="color:#000000"><span style="font-style:italic">in vitro </span></span></span></span><span style="font-size:12pt"><span style="font-family:Times New Roman"><span style="color:#000000">fertilization </span></span></span><span style="font-size:12pt"><span style="font-family:Times New Roman"><span style="color:#000000">(IVF)/intracytoplasmic sperm injection (ICSI) cycles were included in the study. They were randomly </span></span></span><span style="font-size:12pt"><span style="font-family:Times New Roman"><span style="color:#000000">devoted to two groups: experimental (n= 50) and control (n= 50). In the experimental group, 500 IU </span></span></span><span style="font-size:12pt"><span style="font-family:Times New Roman"><span style="color:#000000">hCG passed into the internal cervical orifice via IUI catheter within 15 minutes before the transfer of </span></span></span></div>
<div style="text-align: justify;"><span style="font-size:12pt"><span style="font-family:Times New Roman"><span style="color:#000000">fresh or vitrified cleavage-stage embryos. The control group underwent the same ET procedure </span></span></span><span style="font-size:12pt"><span style="font-family:Times New Roman"><span style="color:#000000">without prior injection of hCG.</span></span></span><br>
</div>
<div style="text-align: justify;"><span style="font-size:12pt"><span style="font-family:TimesNewRomanPS-BoldItalicMT"><span style="color:#000000"><span style="font-weight:bold"><span style="font-style:italic">Results: </span></span></span></span></span><span style="font-size:12pt"><span style="font-family:Times New Roman"><span style="color:#000000">None of the outcomes showed a statistically significant difference between the two groups. </span></span></span><span style="font-size:12pt"><span style="font-family:Times New Roman"><span style="color:#000000">In the intervention and control groups, respectively, biochemical pregnancies rates were 26% and </span></span></span><span style="font-size:12pt"><span style="font-family:Times New Roman"><span style="color:#000000">18%, implantation rates were 13.5% and 8.6%, clinical pregnancies rates were 22% and 14%, ongoing </span></span></span><span style="font-size:12pt"><span style="font-family:Times New Roman"><span style="color:#000000">pregnancies rates were 18% and 14%, and live birth rates were 14% and 12%.</span></span></span><br>
</div>
<div style="text-align: justify;"><span style="font-size:12pt"><span style="font-family:TimesNewRomanPS-BoldItalicMT"><span style="color:#000000"><span style="font-weight:bold"><span style="font-style:italic">Conclusions:</span></span></span></span></span><span style="font-size:12pt"><span style="font-family:Times New Roman"><span style="color:#000000">Intrauterine injection of hCG via IUI catheter is not recommended in a clinical routine </span></span></span><span style="font-size:12pt"><span style="font-family:Times New Roman"><span style="color:#000000">setting at this stage. Future efforts are warranted to further refine the applicability of this modality. </span></span></span></div>
<div style="text-align: justify;"></div>
Assisted reproductive technologies, Embryo transfer, Human chorionic gonadotropin, Intrauterine insemination catheter, Randomized clinical trial.
358
366
http://rbmb.net/browse.php?a_code=A-10-982-1&slc_lang=en&sid=1
Elham
Naghshineh
100319475328460012275
100319475328460012275
No
Department of Obstetrics & Gynecology, School of Medicine, Shahid Beheshti Hospital, Isfahan University of Medical Sciences, Isfahan, Iran
Reihanah
Dehghani Mohammadabadi
100319475328460012276
100319475328460012276
No
Department of Obstetrics & Gynecology, School of Medicine, Shahid Beheshti Hospital, Isfahan University of Medical Sciences, Isfahan, Iran
Ferdous
Mehrabian
100319475328460012277
100319475328460012277
No
Department of Obstetrics & Gynecology, School of Medicine, Shahid Beheshti Hospital, Isfahan University of Medical Sciences, Isfahan, Iran
Hatav
Ghasemi Tehrani
hatav.ghasemi@yahoo.com.
100319475328460012278
100319475328460012278
Yes
Department of Obstetrics & Gynecology, School of Medicine, Shahid Beheshti Hospital, Isfahan University of Medical Sciences, Isfahan, Iran
Mohammad Javad
Tarrahi
100319475328460012279
100319475328460012279
No
Department of Epidemiology and Biostatistics, School of Health, Isfahan University of Medical Sciences, Isfahan, Iran.