Volume 12, Issue 2 (Vol.12 No.2 Jul 2023)                   rbmb.net 2023, 12(2): 269-276 | Back to browse issues page


XML Print


Department of Immunology, School of Medicine, Kermanshah University of Medical Sciences, Kermanshah, Iran.
Abstract:   (1277 Views)
Background:  Allergicrhinitis (AR) is an inflammatory disorder of the nasal mucosa, caused by exposure to environmental allergens. It is known that 15-lipoxygenase (15-LOX) is involved in the biosynthetic pathways of anti-inflammatory lipid mediators, including resolvins and protectins.

Methods: In this study, which was performed on 130 AR patients and 130 healthy controls, we aimed to investigate the association of susceptibility to AR with two selected single-nucleotide polymorphisms (SNPs), that is, rs2619112:A>G and rs7217186:C>T, in the intron regions of arachidonic acid 15-LOX (ALOX15) gene, using SNPinfo and Regulome DB tools.

Results: The results showed that the CT genotype of rs7217186: C>T was significantly associated with the increased risk of AR compared to the CC genotype (P= 0.037, OR=1.943, CI: 1.038-0.638). However, there was no strong evidence of the association of rs2619112: A>G with susceptibility to AR (P> 0.05).

Conclusions: The present results indicated that rs7217186 polymorphism of ALOX15 gene might be a potential biomarker for susceptibility to AR.
Full-Text [PDF 259 kb]   (604 Downloads)    
Type of Article: Original Article | Subject: Immunology
Received: 2023/05/18 | Accepted: 2023/09/15 | Published: 2023/12/20

References
1. Wallace DV, Dykewicz MS, Bernstein DI, Blessing-Moore J, Cox L, Khan DA, et al. The diagnosis and management of rhinitis: an updated practice parameter. J Allergy Clin Immunol. 2008;122(2):S1-S84. [DOI:10.1016/j.jaci.2008.06.003] [PMID]
2. Small P, Kim H. Allergic rhinitis. Allergy Asthma Clin Immunol. 2011;7(1):1-8. [DOI:10.1186/1710-1492-7-S1-S3] [PMID] []
3. Eifan AO, Durham SR. Pathogenesis of rhinitis. Clin Exp Allergy. 2016;46(9):1139-51. [DOI:10.1111/cea.12780] [PMID]
4. Shirkani A, Mansouri A, Farid Hosseini R, Jabbari Azad F, Alsadat Mahmoudian R, Montazer M, et al. The Role of Interleukin-4 and 13 Gene Polymorphisms in Allergic Rhinitis: A Case Control Study. Rep Biochem Mol Biol. 2019;8(2):111-8.
5. Alessandri AL, Sousa LP, Lucas CD, Rossi AG, Pinho V, Teixeira MM. Resolution of inflammation: mechanisms and opportunity for drug development. Pharmacol Ther. 2013;139(2):189-212. [DOI:10.1016/j.pharmthera.2013.04.006] [PMID]
6. Nathan C. Points of control in inflammation. Nature. 2002;420(6917):846-52. [DOI:10.1038/nature01320] [PMID]
7. Eisenhut M, Mizgerd J. Acute lower respiratory tract infection. New Engl J Med. 2008;358:2413-4. [DOI:10.1056/NEJMc080592] [PMID]
8. Davoodi A, Lotfi R, Mortazavi SH, Gorgin Karaji A, Rezaiemanesh A, Salari F. Retinoic Acid Correlates with Reduced Serum IL-10 And TGF-beta in Allergic Rhinitis. Rep Biochem Mol Biol. 2021;9(4):399-407. [DOI:10.52547/rbmb.9.4.399] [PMID] []
9. Serhan CN. Pro-resolving lipid mediators are leads for resolution physiology. Nature. 2014;510(7503):92-101. [DOI:10.1038/nature13479] [PMID] []
10. Serhan CN, Dalli J, Colas RA, Winkler JW, Chiang N. Protectins and maresins: New pro-resolving families of mediators in acute inflammation and resolution bioactive metabolome. Biochim Biophys Acta. 2015;1851(4):397-413. [DOI:10.1016/j.bbalip.2014.08.006] [PMID] []
11. Basil MC, Levy BD. Specialized pro-resolving mediators: endogenous regulators of infection and inflammation. Nat Rev Immunol. 2016;16(1):51-67. [DOI:10.1038/nri.2015.4] [PMID] []
12. Serhan CN, Savill J. Resolution of inflammation: the beginning programs the end. Nat Immunol. 2005;6(12):1191-7. [DOI:10.1038/ni1276] [PMID]
13. Headland SE, Norling LV. The resolution of inflammation: Principles and challenges. Semin Immunol. 2015,27(3):149-60. [DOI:10.1016/j.smim.2015.03.014] [PMID]
14. Ivanov I, Kuhn H, Heydeck D. Structural and functional biology of arachidonic acid 15-lipoxygenase-1 (ALOX15). Gene. 2015;573(1):1-32. [DOI:10.1016/j.gene.2015.07.073] [PMID] []
15. Barnig C, Frossard N, Levy BD. Towards targeting resolution pathways of airway inflammation in asthma. Pharmacol Ther. 2018;186:98-113. [DOI:10.1016/j.pharmthera.2018.01.004] [PMID]
16. Lotfi R, Rezaiemanesh A, Mortazavi SH, Karaji AG, Salari F. Immunoresolvents in asthma and allergic diseases: Review and update. J Cell Physiol. 2019;234(6):8579-8596. [DOI:10.1002/jcp.27836] [PMID]
17. Banerjee S. ALOX15 (arachidonate 15-lipoxygenase). Atlas of Genetics and Cytogenetics in Oncology and Haematology. 2006-06-01. https://atlasgeneticsoncology.org/gene/42986/alox15-(arachidonate-15-lipoxygenase).
18. Okubo K, Kurono Y, Fujieda S, Ogino S, Uchio E, Odajima H, et al. Japanese guideline for allergic rhinitis. Allergol Intl. 2011;60(2):171-89. [DOI:10.2332/allergolint.11-RAI-0334] [PMID]
19. Chacon Cortes DF, Griffiths L. Methods for extracting genomic DNA from whole blood samples: current perspectives. J Biorepository Sci Appl Med. 2014;2014(2):1-9. [DOI:10.2147/BSAM.S46573]
20. Zhang K, Wang Y-y, Liu Q-j, Wang H, Liu F-f, Ma Z-y, et al. Two single nucleotide polymorphisms in ALOX15 are associated with risk of coronary artery disease in a Chinese Han population. Heart and vessels. 2010;25(5):368-73. [DOI:10.1007/s00380-009-1223-5] [PMID]
21. Zhao J, He Z, Ma S, Li L. Association of ALOX15 gene polymorphism with ischemic stroke in Northern Chinese Han population. J Mol Neurosci. 2012;47(3):458-64. [DOI:10.1007/s12031-012-9721-9] [PMID]
22. Kaur N, Singh J, Reddy S. Interaction between ALOX15 polymorphisms and coronary artery disease in North Indian population. Clin Exp Hypertens. 2018;40(4):398-405. [DOI:10.1080/10641963.2017.1384485] [PMID]
23. K Ke YH, Xiao WJ, He JW, Zhang H, Yu JB, Hu WW, et al. Association of ALOX15 gene polymorphisms with obesity-related phenotypes in Chinese nuclear families with male offspring. Acta Pharmacol Sin. 2012;33(2):201-7. [DOI:10.1038/aps.2011.167] [PMID] []
24. Herlin M, McGuigan FE, Luthman H, Åkesson K. Polymorphisms in inflammation associated genes ALOX15 and IL-6 are associated with bone properties in young women and fracture in elderly. Bone. 2015;79:105-9. [DOI:10.1016/j.bone.2015.05.035] [PMID]
25. Cheung CL, Chan V, Kung AW. A differential association of ALOX15 polymorphisms with bone mineral density in pre- and post-menopausal women. Hum Hered. 2008;65(1):1-8. [DOI:10.1159/000106057] [PMID]
26. Kleinstein SE, Heath L, Makar KW, Poole EM, Seufert BL, Slattery ML, et al. Genetic variation in the lipoxygenase pathway and risk of colorectal neoplasia. Genes Chromosomes Cancer. 2013;52(5):437-49. [DOI:10.1002/gcc.22042] [PMID] []

Rights and permissions
Creative Commons License This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.