TY - JOUR JF - rbmb JO - rbmb.net VL - 8 IS - 2 PY - 2019 Y1 - 2019/7/01 TI - SIRT1 Gene Polymorphisms Are Associated with Urinary Bladder Cancer in an Iranian Population TT - N2 - Background: The present study was undertaken to evaluate the possible association between silent information regulator of transcription 1 gene (SIRT 1) polymorphisms and risk of urinary bladder cancer (UBC) in an Iranian population. Methods: The SIRT1 polymorphisms rs3758391 T/C and rs369274325 G/A were evaluated in 120 Iranian bladder cancer patients and 118 healthy individuals as the control group. The SIRT1 rs369274325 G/A and rs3758391 T/C polymorphisms were genotyped using tetra-primer ARMS PCR and PCR-RFLP methods, respectively. Results: The SIRT1 rs3758391 TT genotype occurred significantly more frequently in the UBC patients than in the controls (13.3 vs. 1.7%) in both the additive and recessive models due to a significant difference in either of additive (TT vs. CC; OR= 9.529, P = 0.003) or recessive models (TT vs. CC + CT genotype; OR= 8.923, P = 0.002). Also, for rs369274325, the AG genotype was found in a significantly greater percentage of UBC patients than in controls (75.8 vs. 43.2%, respectively, P < 0.0001. Conclusions: Our preliminary study suggests that SIRT1 rs3758391 T/C and rs369274325 G/A polymorphisms may confer an increased risk of bladder cancer in our patients. SP - 194 EP - 199 AU - Shafieian, Zahra AU - Bahari, Gholamreza AU - Hashemi, Mohammad AU - Nakhaee, Alireza AD - Department of Clinical Biochemistry, School of Medicine, Zahedan University of Medical Sciences, Zahedan, Iran. & Cellular and Molecular Research Center, Zahedan University of Medical Sciences, Zahedan, Iran. KW - Gene polymorphism KW - SIRT1 KW - Urinary Bladder Neoplasms. UR - http://rbmb.net/article-1-311-en.html ER -