RT - Journal Article T1 - Uncoupling Protein 2 Expression Modulates Obesity in Chronic Kidney Disease Patients JF - rbmb YR - 2021 JO - rbmb VO - 10 IS - 1 UR - http://rbmb.net/article-1-639-en.html SP - 119 EP - 125 K1 - Chronic kidney disease (CKD) K1 - obesity K1 - Uncoupling protein 2 (UCP2) gene expression K1 - Real-Time polymerase chain reaction (RT-PCR) AB - Background: Obesity is a multifactorial metabolic disease resulting from behavioral and genetic factors. Obesity is linked to diabetes mellitus and hypertension, which are considered as major risk factors for chronic kidney disease (CKD); moreover, it has a direct effect on developing CKD and end stage renal disease (ESRD). Here was aimed to examine the association between uncoupling protein 2 (UCP2) gene expression and obesity in CKD patients. Methods: UCP2 gene expression was analyzed by real time polymerase chain reaction (RT-PCR) in 93 participants divided into three groups. The groups included 31 non-obese CKD patients, 31 obese CKD patients, and 31 healthy, age-matched, unrelated volunteers as a control group. Results: UCP2 gene expression was significantly relevant when comparing the non-obese CKD and obese CKD groups to the control group (p< 0.001). No significant association was found when the groups were compared by gender; Chi-square (X2) was 2.38 and p= 0.304. A significant negative correlation was found between UCP2 gene expression and BMI in CKD (p< 0.05). Conclusions: These results indicate that UCP2 gene expression plays a significant role as a risk factor for obesity in CKD patients. LA eng UL http://rbmb.net/article-1-639-en.html M3 10.52547/rbmb.10.1.119 ER -