%0 Journal Article %A Mohammed, Hanan Sharaf El-Deen %A Kamal, Manal Mohamed %A ElBadre, Hala Mostafa %A Hosni, Amal %A Elfadl, Azza Abo %A Mostafa, Mohamed Ahmed %A El-Mahdy, Reham Ibrahim %T Lectin-Like OLR1 3′UTR Rs1050286 Gene Polymorphism and Plasma Oxidized-LDL in Coronary Artery Disease and Their Relation to Cardiovascular Risk and Outcomes %J Reports of Biochemistry and Molecular Biology %V 10 %N 4 %U http://rbmb.net/article-1-779-en.html %R 10.52547/rbmb.10.4.537 %D 2022 %K Coronary artery disease, genotyping, OLR1, outcomes, Oxidized low-density lipoprotein., %X Background: Oxidized low-density lipoprotein (ox-LDL) has an important role in the genesis of coronary atherosclerosis. Lectin-like ox-LDL receptor 1 (OLR1) contributes to the uptake and internalization of ox- LDL. Genetic polymorphisms have been associated with coronary artery disease (CAD). Here we explore the association of plasma levels of ox-LDL and 3′ UTR OLR1 (rs1050286) SNP with CAD risk and inhospital adverse outcomes. Methods: A case-control study enrolled 192 patients with ST-segment elevation myocardial infarction (STEMI), 100 patients with unstable angina, and 100 healthy controls. Baseline, clinical characteristics, and risk scores of the patients were determined. Plasma ox-LDL and other biochemical variables were measured. All subjects are genotyped for OLR1 (rs1050286) by RT-PCR with TaqMan SNP genotyping assay. Results: Plasma ox-LDL was higher with enhanced sensitivity and specificity in identifying patients with STEMI and was found as a significant independent risk factor for CAD in those two groups. Levels of ox-LDL were increased with increasing poor prognostic factors in STEMI patients that are associated with an increased incidence of some adverse events and in-hospital mortality. Elevated STEMI risk was associated with T allele of OLR1 (rs1050286) (odds ratio of 4.9, 95% CI: 2.6-9.4, p< 0.001). STEMI patients who have T allele exhibited higher risk scores, coronary multivessel narrowing, and elevated incidence of in-hospital major adverse clinical events. Conclusions: These results suggest that plasma ox-LDL, as well as T allele of ORL-1 (rs1050286), is associated with the increased risk for developing STEMI and the associated adverse clinical outcomes. %> http://rbmb.net/article-1-779-en.pdf %P 537-553 %& 537 %! OLR1 (rs1050286) SNP and Plasma ox-LDL in CAD Risk %9 Original Article %L A-10-839-1 %+ Department of Medical Biochemistry and Molecular Biology, Faculty of Medicine, Assiut University, Assiut, Egypt. %G eng %@ 2322-3480 %[ 2022