TY - JOUR T1 - Comparative Study of New Biomarkers in Iraqi DM2 with and without Complications TT - JF - rbmb JO - rbmb VL - 11 IS - 3 UR - http://rbmb.net/article-1-903-en.html Y1 - 2022 SP - 400 EP - 404 KW - DM2 KW - DN KW - DCVD KW - HbA1C KW - IL-8 KW - Irisin N2 - Background: Recent research indicates that persistent inflammatory responses may contribute to the rise of diabetic nephropathy (DN) and diabetic cardiovascular disease (DCVD) in type 2 diabetes mellitus patients (DM2). Numerous molecules associated with inflammation and angiogenesis have been implicated in the development and progression of DN and DCVD, respectively. Methods: The subjects were separated into five groups: healthy controls (n= 25), type 2 diabetes mellitus patients (n= 30), type 2 diabetes mellitus patients with nephropathy DN (n= 30), and type 2 diabetes mellitus patients with cardiovascular disease DCVD (n= 30). The blood levels of irisin, IL-8, HbA1C, urea, and creatinine were determined. Results: In current study there was high significant increased irisin levels (p< 0.001) in DN patients than other groups and a high significant decreased IL-8 level in DCVD. Conclusions: Serum IL-8 and irisin levels may serve as early indicators of DM2 problems (DN, DCVD). M3 10.52547/rbmb.11.3.400 ER -