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en RT-qPCR Analysis of LAMP3 (CD208) Gene Expression in Oral Lichen Planus and Oral Squamous Cell Carcinoma ایمنی شناسی Immunology مقالات اصلی Original Article <div style="text-align: justify;">Background: Many new studies have been conducted on cellular proteins to use them as prognostic markers or in target therapy through determining the increase or decrease in their expression in the lichen planus and OSCC. LAMP3 protein is one of these proteins which has been recently considered. Thus, considering the unknown etiology of lichen planus, significance of their early diagnosis and treatment and lack of a suitable and final treatment for this disease and oral cancers, and preventing the progression of lichen planus, which can turn into OSCC, we decided to investigate the level of expression of this gene and its effect on the progression, study the connection between these two conditions and the probable factors contributing to their etiopathogenesis. Methods: In this study, ninety-four paraffin blocks tissue samples of patients were obtained together with their demographic documents. LAMP3 expression was measured RT-qPCR method. Results: The results show that there is not any significant difference between age and sex population of our study. in squamous cell carcinoma the amount of expression of LAMP3 was higher than lichen planus and healthy margin. Average LAMP3 Gene expression in grade III was higher than group grade I & II in which considering significant level of 5%, it is statistically significant. Conclusions: According to the findings of this study, it can be concluded that the expression of the LAMP3 gene in SCC lesions is higher than in healthy tissue. Hence, LAMP3 gene expression can be used as a diagnostic biomarker.</div> CD208 protein, LAMP3 protein, oral Lichen Planus, Oral Squamous Cell Carcinoma. 36 41 http://rbmb.net/browse.php?a_code=A-10-1190-1&slc_lang=en&sid=1 Farnaz Mohajer Tehran 100319475328460017802 100319475328460017802 No Oral and Maxillofacial Pathology Department, Oral and Maxillofacial Diseases Research Center, Faculty of Dentistry, Mashhad University of Medical Sciences & Oral and Maxillofacial Diseases Research Center, Mashhad University of Medical Sciences, Mashhad, Iran. Nooshin Mohtasham 100319475328460017803 100319475328460017803 No Oral and Maxillofacial Pathology Department, Oral and Maxillofacial Diseases Research Center, Faculty of Dentistry, Mashhad University of Medical Sciences. Mojtaba Ahmadi 100319475328460017804 100319475328460017804 No 2: Oral and Maxillofacial Diseases Research Center, Mashhad University of Medical Sciences, Mashhad, Iran. Mehdi Shahabinejad shahabinejadm@mums.ac.ir 100319475328460017805 100319475328460017805 Yes Oral and Maxillofacial Pathology Department, Oral and Maxillofacial Diseases Research Center, Faculty of Dentistry, Mashhad University of Medical Sciences. Maryam Mohammadi* maryam_mohammadi16@yahoo.com 100319475328460017806 100319475328460017806 No Oral and Maxillofacial Diseases Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.