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en Clinical Significance of Serum TNF-a and IL-6 Levels in Patients with Metabolic Syndrome ایمنی شناسی Immunology مقالات اصلی Original Article <div style="text-align: justify;">Background: Several components of metabolic syndrome (MetS) facilitate its diagnosis, including abdominal obesity, hyperlipidemia, high blood pressure, and insulin resistance. The production of tumor necrosis factor-alpha (TNF-alpha) and interleukin 6 (IL-6) seem to be associated with MetS components. The aim of this study was to evaluate the correlation between the serum levels of TNFα and IL-6 with metabolic syndrome and its components. Methods: This case-control study investigated a total of 250 subjects, comprising 125 healthy controls from the Kerman Blood Transfusion Organization and 125 metabolic syndrome patients. Serum IL-6 and TNF-a levels were measured using the ELISA technique. Results: There was a significant increase in the serum levels of TNF-a and IL-6 in patients with metabolic syndrome compared with the controls. However, a lack of correlation between MetS components and TNF-a and IL-6 serum levels was detected. Conclusions: Patients with MetS had significantly raised serum IL-6 and TNF-a levels compared with the controls, supporting the evidence that inflammation plays an important role in the immunopathogenesis of the disease. Additionally, serum levels of IL-6 and TNF-a are suggested as valuable predicting factors for MetS. The lack of association between IL-6 and TNF-a serum levels and MetS components remains to be investigated by further research.</div> IL-6, TNF-a, metabolic syndrome, metabolic syndrome components 74 79 http://rbmb.net/browse.php?a_code=A-10-48-1&slc_lang=en&sid=1 Mojgan Mohammadi mohammadimzh@mums.ac.ir 10031947532846006237 10031947532846006237 No Immunology Research Center Mohammad Hossein Gozashti gozashti@kmu.ac 10031947532846006238 10031947532846006238 No Physiology Research Center Majid Aghadavood majiddavid12@gmail.com 10031947532846006239 10031947532846006239 No Department of Gastroenterology Mohammad Reza Mehdizadeh Drmehdizadeh20@yahoo.com 10031947532846006240 10031947532846006240 No Mohammad Mahdi Hayatbakhsh m24672@yahoo.com 10031947532846006241 10031947532846006241 Yes Gastroenterology and Hepatology Research Center, Institute of Basic and Clinical Physiology sciences, kerman University of Medical Sciences, Kerman, Iran