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'); Reports of Biochemistry and Molecular Biology rbmb.net Basic Sciences http://rbmb.net 1 admin 2322-3480 2322-3480 10.61882/rbmb en jalali 1396 7 1 gregorian 2017 10 1 6 1 online 1 fulltext
en Lack of an Association between a Functional Polymorphism in the MDM2 Promoter and Breast Cancer in Women in Northeast Iran زیست شناسی ملکولی Molecular Biology مقالات اصلی Original Article <p style="text-align: justify;"><strong>Background: </strong>Breast cancer is one of the most common cancers among women worldwide. Tumor protein 53 (TP53) and its regulator the mouse double murine 2 (MDM2) have important roles in tumorigenesis by playing key roles in cell division and response to DNA damage. MDM2 SNP309 T>G (rs2279744) polymorphism in the promoter region of MDM2 gene can cause dysfunction and inactivation of TP53 which promote tumor progression as a result. The aim of this study was to investigate the association between this polymorphism and risk of breast cancer in northeastern Iranian population.</p> <p style="text-align: justify;"><strong>Material:</strong> A case-control study with 128 breast cancer patients and 143 healthy women was conducted. PCR-ARMS was performed to assess the MDM2 SNP309 T>G (rs2279744) polymorphism.</p> <p style="text-align: justify;"><strong>Results:</strong> The GG Genotype frequency between patients and controls showed no significant association between this polymorphism with breast cancer risk (p=0.116, OR [95% CI]: 1.267 [0.616, 2.603]). Also, G allele frequency was not associated with breast cancer risk in studied population (p=0.143, OR [95% CI]: 1.326 [0.908, 1.935]). For this polymorphism, a significant difference of 8.0 years in the average age of cancer diagnosis was observed between TT and TG carriers (40.57 versus 48.15 years, p = 0.029).</p> <p style="text-align: justify;"><strong>Conclusion: </strong>The results of this study suggest that the SNP309 T>G polymorphism in the MDM2 gene may not be associated with the risk of breast cancer in an Iranian population</p> Breast cancer, Case-control study, Mouse double murine 2 (MDM2), Polymorphism 112 117 http://rbmb.net/browse.php?a_code=A-10-51-1&slc_lang=en&sid=1 Zeinab Tavakkol Afshari zainabtavakoli82@gmail.com 10031947532846006262 10031947532846006262 No Immunogenetic and Cell Culture Department, Immunology Research Center, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran Amin Reza Nikpoor nikpoora901@mumsl.com 10031947532846006263 10031947532846006263 No Immunogenetic and Cell Culture Department, Immunology Research Center, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran Jalil Tavvakol Afshari tavakkolaj@mums.ac.ir 10031947532846006264 10031947532846006264 No Immunogenetic and Cell Culture Department, Immunology Research Center, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran Rashin Ganjali ganjalir@mums.ac.ir 10031947532846006265 10031947532846006265 No Immunogenetic and Cell Culture Department, Immunology Research Center, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran Parvaneh Sanglakh Ghoochan Atigh jamialahmadikh@mums.ac.ir 10031947532846006266 10031947532846006266 No Biochemistry Department, Mashhad Payame Noor University, Mashhad, Iran Fatemeh Homaei Shandiz homaiesh@mums.ac.ir 10031947532846006267 10031947532846006267 No Cancer Research Center, Mashhad University of Medical Sciences, Mashhad, Iran Khadijeh Jamialahmadi jamialahmadikh@mums.ac.ir 10031947532846006268 10031947532846006268 Yes Department of Medical Biotechnology, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran