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en Circulating miR-21 Overexpression Correlates with PDCD4 and IL-10 in Systemic Lupus Erythematosus (SLE): A Promising Diagnostic and Prognostic Biomarker ایمنی شناسی Immunology مقالات اصلی Original Article <div style="text-align: justify;">Background:  Systemic Lupus Erythematosus (SLE) is a chronic autoimmune condition that affects multiple organs significantly impacts morbidity and mortality. The development of SLE is influenced by genetic predisposition and dysregulated immune response. Our objective was to investigate miR-21, IL-10, and PDCD4 expression in SLE patient plasma and analyze their correlations and potential diagnostic and prognostic values. Methods: The study included 100 healthy subjects, 50 newly diagnosed (ND), and 50 under-treatment (UT) SLE patients. The patients were observed for 24 weeks to track relapses. miR-21 and PDCD4 gene expression levels were measured using real-time RT-PCR, and IL-10 production was measured using ELISA. Results: miR-21 and IL-10 expression levels were significantly greater in SLE patients than in healthy subjects, with the highest levels observed in ND patients. PDCD4 expression was also significantly greater in SLE patients than in subjects, with the highest levels observed in UT patients. ROC curve analyses and Cox-Mantel Log-rank tests indicated miR-21, PDCD4, and IL-10 as proper diagnostic and prognostic biomarkers for SLE. The study also revealed a significant positive correlation between miR-21 and PDCD4 and IL-10 levels in SLE patients. Conclusions: The studies suggest that dysregulation of miR-21, PDCD4, and IL-10 in patients with SLE may contribute to disease development and provides new diagnostic and prognostic markers. Additionally, the observed correlation between miR-21, PDCD4, and IL-10 levels in SLE patients signifies a potential interplay between these molecules.</div> Interleukin-10 (IL-10), Microrna-21 (miR-21), Programmed Cell Death 4 Protein (PDCD4), Systemic Lupus Erythematosus (SLE). 220 232 http://rbmb.net/browse.php?a_code=A-10-1306-1&slc_lang=en&sid=1 Nibras Kamil Alhassbalawi 100319475328460017906 100319475328460017906 No Department of Immunology, Faculty of Medicine, Golestan University of Medical Sciences, Gorgan, Iran. Mojtaba Zare Ebrahimabad 100319475328460017907 100319475328460017907 No Metabolic Disorders Research Center, Golestan University of Medical Sciences, Gorgan, Iran. Fakhri Sadat Seyedhosseini 100319475328460017908 100319475328460017908 No Laboratory Sciences Research Center, Golestan University of Medical Sciences, Gorgan, Iran. Yasser Bagheri 100319475328460017909 100319475328460017909 No Department of Immunology, Faculty of Medicine, Golestan University of Medical Sciences, Gorgan, Iran. Nafiseh Abdollahi 100319475328460017910 100319475328460017910 No Golestan Rheumatology Research Center, Golestan University of Medical Sciences, Gorgan, Iran. Alireza Nazari 100319475328460017911 100319475328460017911 No Department of Surgery, Faculty of Medicine, Rafsanjan University of Medical Sciences, Rafsanjan, Iran. Saeed Mohammadi s.mohammadi@goums.ac.ir 100319475328460017912 100319475328460017912 Yes Golestan Research Center of Gastroenterology and Hepatology, Golestan University of Medical Sciences, Gorgan, Iran & Infectious Diseases Research Center, Golestan University of Medical Sciences, Gorgan, Iran. Yaghoub Yazdani* yazdani@goums.ac.ir 100319475328460017913 100319475328460017913 No Laboratory Sciences Research Center, Golestan University of Medical Sciences, Gorgan, Iran.