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en Association of Alzheimer's Disease with Promoter Variations in NPY2R Gene زیست شناسی ملکولی Molecular Biology مقالات اصلی Original Article <div style="text-align: justify;">Background: Alzheimer's disease (AD) is a widespread neurodegenerative disorder among the elderly, characterized by dementia. The development of AD is significantly influenced by genetic risk factors. Methods: in this study, we have investigated the impact of rs2234759 and rs12507396 polymorphisms in the neuropeptide Y receptor Y2 (NPY2R) gene on AD. Nineteen AD patients and nineteen healthy controls were enlisted in our research. and the DNA samples of all participants were genotyped using amplification refractory mutation system-polymerase chain reaction (ARMS-PCR). Results: The results revealed a noteworthy association between rs2234759 and AD, with a noticeable difference observed in the frequency of genotypes and alleles of this polymorphism between patients and healthy controls (P< 0.001 for both). However, no significant difference was detected in the genotype distribution concerning the rs12507396 polymorphism between the two groups. Conclusion: Our findings provide compelling evidence of an association between the rs2234759 polymorphism in NPY2R and Alzheimer's disease. Given the significant role of NPY2R in brain tissue, this particular polymorphism may result in strengthened presynaptic inhibition of glutamate release.</div> Alzheimer's Disease, Genes, NPY2 receptor, Single Nucleotide Polymorphism. 507 515 http://rbmb.net/browse.php?a_code=A-10-1316-1&slc_lang=en&sid=1 Mohammad Reza Karimzadeh 100319475328460021650 100319475328460021650 No Department of Medical Genetics, Afzalipour School of medicine, Kerman University of Medical Sciences, Kerman, Iran. Atefeh Najmadini 100319475328460021651 100319475328460021651 No Department of Medical Genetics, Afzalipour School of medicine, Kerman University of Medical Sciences, Kerman, Iran. Sara Azhdari 100319475328460021652 100319475328460021652 No Department of Anatomy and Embryology, School of Medicine, Bam University of Medical Sciences, Bam, Iran. Negin Zatalian 100319475328460021653 100319475328460021653 No Department of Genetics, Reproductive Biomedicine Research Center, Royan Institute for Reproductive Biomedicine, ACECR, Tehran, Iran. Fatemeh Zandi 100319475328460021654 100319475328460021654 No Department of Medical Genetics, Afzalipour School of medicine, Kerman University of Medical Sciences, Kerman, Iran. Neda Salmani 100319475328460021655 100319475328460021655 No Department of Medical Genetics, Afzalipour School of medicine, Kerman University of Medical Sciences, Kerman, Iran. Kolsoum Saeidi K_saeidi@kmu.ac.ir. 100319475328460021656 100319475328460021656 Yes Neurology Research Center, Kerman University of Medical Sciences, Kerman, Iran.