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en Common Variations in Perilipin rs1052700 and FTO rs3751812 Genes, Central Obesity, and Risk Type-2 Diabetes زیست شناسی ملکولی Molecular Biology مقالات اصلی Original Article <div style="text-align: justify;">Background: Perilipins are proteins at the external level of the lipid glob in adipocytes steroid-generating cells and play a central role in lipid storage and breakdown. FTO gene is associated with Type-2 diabetes (T2D) and increased fat mass. Association of Perilipin and FTO genes polymorphism with T2D was investigated. Methods: Clinical traits in a random sample of 183 Iranian men and women with T2D and 174 controls without any metabolic disease took part in the study. The sample was genotyped using Tetra-ARMS method. Results: In Perilipin (rs1052700) polymorphism tested, a significant association was found between this polymorphism and T2D (P=0.03). In FTO (rs3751812) polymorphism, a significant association was seen between this gene and obesity (P=0.003). But, no significant relation was found between this genotype and T2D. Conclusion: The rs3751812 polymorphism of FTO gene is the major genetic determinant of obesity, but not type-2 diabetes. The rs1052700 polymorphism of Perilipin gene is related to T2D but not obesity.</div> Type-2 diabetes, FTO, Perilipin, gene polymorphism 80 87 http://rbmb.net/browse.php?a_code=A-10-53-1&slc_lang=en&sid=1 Ramin Saravani saravaniramin@yahoo.com 10031947532846006242 10031947532846006242 Yes Cellular and Molecular Research Center, Zahedan University of Medical Sciences, Zahedan, Iran - Department of Clinical Biochemistry, School of Medicine, Zahedan University of Medical Sciences, Zahedan, Iran. Hamid Reza Galavi H.R_Galavi2010@yahoo.com 10031947532846006243 10031947532846006243 No Cellular and Molecular Research Center, Zahedan University of Medical Sciences, Zahedan, Iran - Department of Clinical Biochemistry, School of Medicine, Zahedan University of Medical Sciences, Zahedan, Iran. Nafiseh Noorzehi nafisenourzehi@gmail.com 10031947532846006244 10031947532846006244 No Department of Biology, Zabol University, Zabol, Iran Nasrin Ranjbar Ranjbar2014@yahoo.com 10031947532846006245 10031947532846006245 No Department of Clinical Biochemistry, School of Medicine, Zahedan University of Medical Sciences, Zahedan, Iran Fatemeh Mollashahee-Kohkan fatemeh64wowo@gmail.com 10031947532846006246 10031947532846006246 No Department of Clinical Biochemistry, School of Medicine, Zahedan University of Medical Sciences, Zahedan, Iran