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en Association of Circulating Circular RNAs (hg38_circ_0008980, and CircDLGAP4) in Diagnosis, Diseases Severity, and Prognosis of Ischemic Stroke زیست شناسی ملکولی Molecular Biology مقالات اصلی Original Article <div class="WordSection1"> <div style="text-align: justify;">Background: Fast diagnosing ischemic stroke (IS) is a critical issue in clinical studies, as it allows more effective therapy and stops the progression of IS. The blood level of circular RNAs (CircRNAs) after stroke may be a rapid diagnostic marker. Methods: In this study, the blood level of circRNAs was evaluated using a real-time polymerase chain reaction (PCR). We used logistic and linear regression analysis to assess the potential of circRNAs levels with the risk of IS. Results: circRNA DLG associated protein 4 (CircDLGAP4) was decreased in patients compared with controls, and logistic regression showed its expression negatively associated with IS risk. The expression level of human genome version 38_Circular_0008980 (hg38_circ_0008980) was reduced significantly in patients with small vessel disease (SVD), and the linear regression analysis showed a negative relationship between hg38_circ_0008980 expressions with SVD subtype. hg38_circ_0008980 expression relative to controls showed a significant association with IS risk. Conclusions: Taken together, we found a significant decrease in the level of hg38_circ_0008980 after IS; it may act as a novel circRNA in IS pathophysiology with a positive correlation with stroke severity.</div> </div> <div style="text-align: justify;"><div aria-label="Page Break" class="cke_pagebreak" contenteditable="false" data-cke-display-name="pagebreak" data-cke-pagebreak="1" style="page-break-after:always" title="Page Break"></div></div> Biomarkers, Circular RNAs, Ischemic strokes. 476 486 http://rbmb.net/browse.php?a_code=A-10-1320-1&slc_lang=en&sid=1 Mastaneh Zeraatiannejad 100319475328460018613 100319475328460018613 No Department of Biology, Zarghan Branch, Islamic Azad University, Zarghan, Iran. Mohammad Javad Mokhtari mj.mokhtari@iau.ac.ir 100319475328460018614 100319475328460018614 Yes Department of Biology, Zarghan Branch, Islamic Azad University, Zarghan, Iran. Afshin Borhani-Haghighi 100319475328460018615 100319475328460018615 No Clinical Neurology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.