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en The Role of Vitamin D Binding Protein and Vitamin D Level in Mortality of Sepsis Patients زیست شناسی ملکولی Molecular Biology مقالات اصلی Original Article <div style="text-align: justify;">Background: Vitamin D plays crucial roles in immune cell function, including macrophage activation, immune response modulation, and antimicrobial peptide production. Low vitamin D levels can result in reduced immune response, heightened inflammation, and impaired organ function, thereby exacerbating sepsis severity and impacting patient prognosis. This study investigates the influence of vitamin D binding protein expression and vitamin D levels on the mortality of septic patients. Methods: This analytical observational study employs a case-control approach and involves patients at the Critical Care Unit of Dr. M. Djamil General Hospital in Padang, Indonesia. The study comprises 40 patients in the case group and 40 patients in the control group. Vitamin D and vitamin D binding protein levels are assessed using the enzyme-linked immunosorbent assay method. Results: Vitamin D and vitamin D binding protein levels were observed to be lower in the case group compared to the control group. In the case group, the majority of patients had vitamin D binding protein levels below 200 µg/mL. A significant association was found between vitamin D levels and mortality in sepsis patients (P< 0.05). Patients with vitamin D levels below 20 µg/mL faced a 2.54 times higher risk of mortality than those with levels exceeding 20 µg/mL. Conclusions: Diminished levels of vitamin D binding protein and vitamin D contribute to an increased risk of mortality in septic patients.</div> Antiinflammation, Mortality, Sepsis, Vitamin D Binding Protein, Vitamin D level. 366 373 http://rbmb.net/browse.php?a_code=A-10-1325-1&slc_lang=en&sid=1 Liliriawati Ananta Kahar lili_anestintensivist@yahoo.com 100319475328460018550 100319475328460018550 Yes Department of Anesthesiology and Intensive Care, Faculty of Medicine, Andalas University, Dr. M. Djamil General Hospital, Padang, 25171, Indonesia. Yusrawati Yusrawati 100319475328460018551 100319475328460018551 No Department of Obstetrics and Gynecology, Faculty of Medicine, Andalas University, Padang, 25171, Indonesia. Jamsari Jamsari 100319475328460018552 100319475328460018552 No Department of Biotechnology, Postgraduate Program, Andalas University, Padang, 25163, Indonesia. Tinni Maskoen 100319475328460018553 100319475328460018553 No Faculty of Medicine, Padjadjaran University, Bandung, 45363, Indonesia. Kornelis Aribowo 100319475328460018554 100319475328460018554 No Department of Pulmonology and Respiratory Medicine, Faculty of Medicine, Andalas University, Padang, 25171, Indonesia. Wiwi Monika Sari 100319475328460018555 100319475328460018555 No Intensive Care Unit, Dr. M. Djamil General Hospital, Padang, 25171, Indonesia.