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en An In vitro Study on Curcumin Delivery by Nano-Micelles for Esophageal Squamous Cell Carcinoma (KYSE-30) زیست شناسی ملکولی Molecular Biology مقالات اصلی Original Article <div style="text-align: justify;">Background: The incidence of esophageal squamous cell carcinoma (ESCC) is increasing, causing catastrophic health burdens on communities. Curcumin has shown promise as a therapeutic agent in the treatment of colon, colorectal, pancreatic, and esophageal cancers but it has very poor bioavailability. The application of nano-carriers as drug delivery systems increases curcumin's bioavailability. Cyclin D1 is overexpressed in ESCC and curcumin may change its expression. Methods: In this study, the effect of SinaCurcumin®, a novel nano-micelle product containing 80 mg curcumin, on the growth of KYSE-30 cells and expression of cyclin D1, was investigated. Paclitaxel and Carboplatin served as reference drugs. Results: Nano-curcumin increased cell cytotoxicity, decreased IC50, and down-regulated of cyclin D1. However, treatment of cells with nano-curcumin might result in multidrug resistance. Conclusions: Nano-curcumin suppressed proliferation of KYSE-30 cells and expression of cyclin D1 although its use in combination with other chemotherapeutic agents requires further testing.</div> Curcumin, Cyclin D1 gene, Drug resistance, KYSE-30 cells, Nano-Micelle 137 143 http://rbmb.net/browse.php?a_code=A-10-61-1&slc_lang=en&sid=1 Sare Hosseini HosseiniSH@mums.ac.ir 10031947532846006269 10031947532846006269 No Cancer Research Center, Mashhad University of Medical Sciences, Mashhad, Iran Jamshidkhan Chamani chamanijk@ibb.ut.ac.ir 10031947532846006270 10031947532846006270 No Department of Biology, Faculty of Sciences, Islamic Azad University-Mashhad Branch, Mashhad, Iran. Hamidreza Rahimi Rahimihr@mums.ac.ir 10031947532846006271 10031947532846006271 Yes Department of Modern Sciences & Technologies, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran. Navid Azmoodeh AzmoodehN11@mums.ac.ir 10031947532846006272 10031947532846006272 No Department of Biology, Faculty of Sciences, Islamic Azad University-Mashhad Branch, Mashhad, Iran. Faezeh Ghasemi ghasemi_8008@yahoo.com 10031947532846006273 10031947532846006273 No Department of Biotechnology, Faculty of Medicine, Arak University of Medical Sciences, Arak, Iran. Porya Hassan Abadi pxh3100@student.bham.ac.uk 10031947532846006274 10031947532846006274 No School of Medicine, University of Birmingham, Birmingham, UK.