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en Protective Effects of Zingerone on Oxidative Stress in Doxorubicin-Induced Rat Hepatotoxicity زیست شناسی ملکولی Molecular Biology مقالات اصلی Original Article <pre style="text-align: justify;"> Background: Doxorubicin, a commonly utilized anthracycline antibiotic and chemotherapeutic agent, has been associated with hepatotoxicity as an adverse effect. This study aimed to evaluate protective effects of zingerone, a bioactive compound derived from ginger renowned for its antioxidative attributes, on oxidative stress in doxorubicin-induced rat hepatotoxicity. Methods: In this experimental study, a total of 48 male Wistar rats were allocated into six distinct groups. The first group received a control treatment of normal saline. The second group was administered an intraperitoneal dose of 20 mg/kg of doxorubicin on day 5. The third group received an oral dose of 40 mg/kg of zingerone for 8 days. The fourth, fifth, and sixth groups were administered zingerone at doses of 10, 20, and 40 mg/kg, respectively, for the same 8-day period. On day 5, all groups, except the control group, received an intraperitoneal injection of doxorubicin. Following a 72-hour interval, the animals were anesthetized, and blood samples were collected to assess serum factors. Moreover, portions of the liver tissue were subjected to histopathological analysis and assessment of oxidative stress parameters. Results: The activity levels of serum enzymes, including aspartate transaminase (AST), alanine transaminase (ALT), and liver malondialdehyde (MDA), increased in the doxorubicin group. Conversely, the levels of other parameters such as glutathione peroxidase (GPX), superoxide dismutase (SOD), and glutathione (GSH) decreased. However, the co-administration of zingerone effectively reversed these levels, restoring them back to normal. Conclusion: These findings suggest that zingerone, particularly at a high dose, exhibit a hepatoprotective effect in the doxorubicin-induced hepatotoxicity model. </pre> Doxorubicin, Hepatotoxicity, Oxidative stress, Zingerone. 575 585 http://rbmb.net/browse.php?a_code=A-10-1318-2&slc_lang=en&sid=1 Rezvan Motamedi 100319475328460020227 100319475328460020227 No Toxicol Research Center, Medical Basic Sciences Research Institute, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran. Soheila Aminzadeh 100319475328460020228 100319475328460020228 No Toxicol Research Center, Medical Basic Sciences Research Institute, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran & Department of Toxicol, School of Pharmacy, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran. Mohammad Javad Khodayar 100319475328460020229 100319475328460020229 No Toxicol Research Center, Medical Basic Sciences Research Institute, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran & Department of Toxicol, School of Pharmacy, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran. Layasadat Khorsandi 100319475328460020230 100319475328460020230 No Cellular and Molecular Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran. Maryam Salehcheh salehche-m@ajums.ac.ir 100319475328460020231 100319475328460020231 Yes Toxicol Research Center, Medical Basic Sciences Research Institute, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran & Department of Toxicol, School of Pharmacy, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.