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'); Reports of Biochemistry and Molecular Biology rbmb.net Basic Sciences http://rbmb.net 1 admin 2322-3480 2322-3480 10.61882/rbmb en jalali 1396 7 1 gregorian 2017 10 1 6 1 online 1 fulltext
en Paraoxonase 1 Activity, Lipid Profile, and Atherogenic Indexes Status in Coronary Heart Disease تخصصي Special مقالات اصلی Original Article <p style="text-align: justify;"><strong><em>Background:</em></strong> Dyslipidemia is considered an independent risk factor for coronary heart disease (CHD). In the present study, we examined lipid profiles and paraoxonase 1 (PON1) activity and atherogenic indexes status and the relationship of PON1 activity by high-density lipoprotein (HDL) and atherogenic indexes in CHD patients and healthy people.</p> <p style="text-align: justify;"><strong><em>Methods:</em></strong> The aim of the study was to compare PON1, lipid profiles, and atherogenic indexes in CHD patients and healthy people as controls. This study enrolled 50 CHD patients and 50 matched healthy controls. Serum activities of PON1 and levels of triglyceride (TG), total cholesterol (TC), low density lipoprotein (LDL), very low density lipoprotein (VLDL), high-density lipoprotein cholesterol (HDL-C), fasting blood glucose (FBG), and atherogenic indexes were analyzed. Data were analyzed by unpaired Student&rsquo;s <em>t </em>tests. Coefficients of correlation were calculated using Pearson&rsquo;s correlation analysis.</p> <p style="text-align: justify;"><strong><em>Results:</em></strong> Levels of TG, TC, LDL, VLDL, FBG, and atherogenic indexes, atherogenic coefficients, and cardiac risk ratios were significantly greater in CHD patients than in controls. Paraoxonase 1 activity and HDL-C levels were significantly less in CHD patients than in controls. Also, PON1 activity correlated positively with HDLC and negatively with atherogenic coefficient, and cardiac risk ratios 1 and 2 in CHD patients.</p> <p style="text-align: justify;"><strong><em>Conclusions:</em></strong> This study showed that CHD is associated with high lipid levels and atherogenic indexes, and low PON1 activity and HDL-C concentrations. Coronary heart disease is a pernicious disease requiring prolonged medical management and hypolipidemic drugs.</p> Atherogenic index, Coronary heart disease, Lipid profile, Paraoxonase 1 1 7 http://rbmb.net/browse.php?a_code=A-10-1-77&slc_lang=en&sid=1 Mostafa Cheraghi 10031947532846002195 10031947532846002195 No Department of Cardiology, Madani Heart Center, Lorestan University of Medical Sciences, Khorramabad, Iran. Gholamreza Shahsavari reza_shahsavari@yahoo.com 10031947532846002196 10031947532846002196 Yes Razi Herbal Researches Center, Lorestan University of Medical Sciences, Khorramabad, Iran Ali Maleki 10031947532846002197 10031947532846002197 No Department of Cardiology, Madani Heart Center, Lorestan University of Medical Sciences, Khorramabad, Iran. Hassan Ahmadvand 10031947532846002198 10031947532846002198 No Razi Herbal Researches Center, Lorestan University of Medical Sciences, Khorramabad, Iran-Department of Biochemistry, Faculty of Medicine, Lorestan University of Medical Sciences, Khorramabad, Iran.