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Reports of Biochemistry and Molecular Biology
rbmb.net
Basic Sciences
http://rbmb.net
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admin
2322-3480
2322-3480
10.61882/rbmb
en
jalali
1403
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gregorian
2024
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fulltext
en
Catechin Hydrate Improves Hypertrophic Scar in Rabbit Ear Model via Reduction of Collagen Synthesis
زیست شناسی سلولی
Cell Biology
مقالات اصلی
Original Article
<div class="WordSection1">
<div style="text-align: justify;"><span style="page:WordSection1"><span style="font-size:10pt"><span style="text-justify:kashida"><span style="text-kashida:0%"><span style="line-height:normal"><span style="tab-stops:396.55pt"><span style="font-family:Calibri,sans-serif"><b><i><span lang="EN-GB" style="font-size:12.0pt"><span new="" roman="" style="font-family:" times=""><span style="color:black">Background:</span></span></span></i></b> <span style="font-size:12.0pt"><span new="" roman="" style="font-family:" times=""><span style="color:black">Hypertrophic scar (HS) is a cutaneous condition results from abnormal wound healing following deep tissue injury. To date, there is no optimal treatment for this skin disorder. Catechins possess anti-inflammatory, antioxidant and anti-fibrotic properties. In this study we investigated the effects of catechin hydrate (CH) in rabbit ear model of HS.</span></span></span></span></span></span></span></span></span><br>
<br>
<span style="font-size:10pt"><span style="text-justify:kashida"><span style="text-kashida:0%"><span style="line-height:normal"><span style="tab-stops:396.55pt"><span style="font-family:Calibri,sans-serif"><b><i><span style="font-size:12.0pt"><span new="" roman="" style="font-family:" times=""><span style="color:black">Methods:</span></span></span></i></b><span style="font-size:12.0pt"><span new="" roman="" style="font-family:" times=""><span style="color:black"> A rabbit ear model of hypertrophic scar was set up. Ten New Zealand white rabbit were divided into 5 equal groups: non-treatment group, vehicle control, treated with intralesional injection of dimethyl sulfoxide (DMSO), and test groups, received intralesional injection of CH/DMSO solution at concentration of 0.25, 1.25 and, 2.5 mg/ml, respectively. The treatments were initiated </span></span></span><b><span dir="RTL" lang="AR-SA" style="font-size:12.0pt"><span new="" roman="" style="font-family:" times=""><span style="color:black">‏</span></span></span></b><b><span lang="AR-SA" style="font-size:12.0pt"><span new="" roman="" style="font-family:" times=""><span style="color:black">‎</span></span></span></b><span style="font-size:12.0pt"><span new="" roman="" style="font-family:" times=""><span style="color:black">35 days after wounding once a </span></span></span><b><span dir="RTL" lang="AR-SA" style="font-size:12.0pt"><span new="" roman="" style="font-family:" times=""><span style="color:black">‏</span></span></span></b><span style="font-size:12.0pt"><span new="" roman="" style="font-family:" times=""><span style="color:black">week for </span></span></span><b><span dir="RTL" lang="AR-SA" style="font-size:12.0pt"><span new="" roman="" style="font-family:" times=""><span style="color:black">‏</span></span></span></b><b><span lang="AR-SA" style="font-size:12.0pt"><span new="" roman="" style="font-family:" times=""><span style="color:black">‎</span></span></span></b><span style="font-size:12.0pt"><span new="" roman="" style="font-family:" times=""><span style="color:black">4 </span></span></span><b><span lang="AR-SA" style="font-size:12.0pt"><span new="" roman="" style="font-family:" times=""><span style="color:black">‎</span></span></span></b><span style="font-size:12.0pt"><span new="" roman="" style="font-family:" times=""><span style="color:black">weeks</span></span></span><b><span lang="AR-SA" style="font-size:12.0pt"><span new="" roman="" style="font-family:" times=""><span style="color:black">‎</span></span></span></b><span style="font-size:12.0pt"><span new="" roman="" style="font-family:" times=""><span style="color:black">.</span></span></span><b><span lang="AR-SA" style="font-size:12.0pt"><span new="" roman="" style="font-family:" times=""><span style="color:black">‎ ‏</span></span></span></b><span style="font-size:12.0pt"><span new="" roman="" style="font-family:" times=""><span style="color:black"> The scar elevation index (SEI) and the epidermal thickness index (ETI) were measured using Hematoxylin and Eosin (H&E) </span></span></span><b><span dir="RTL" lang="AR-SA" style="font-size:12.0pt"><span new="" roman="" style="font-family:" times=""><span style="color:black">‏</span></span></span></b><span style="font-size:12.0pt"><span new="" roman="" style="font-family:" times=""><span style="color:black">staining and the amount of collagen deposition were determined after Masson</span></span></span><b><span lang="AR-SA" style="font-size:12.0pt"><span new="" roman="" style="font-family:" times=""><span style="color:black">‎</span></span></span></b><span style="font-size:12.0pt"><span new="" roman="" style="font-family:" times=""><span style="color:black">' </span></span></span><b><span lang="AR-SA" style="font-size:12.0pt"><span new="" roman="" style="font-family:" times=""><span style="color:black">‎</span></span></span></b><span style="font-size:12.0pt"><span new="" roman="" style="font-family:" times=""><span style="color:black">trichrome staining</span></span></span><b><span lang="AR-SA" style="font-size:12.0pt"><span new="" roman="" style="font-family:" times=""><span style="color:black">‎</span></span></span></b><span style="font-size:12.0pt"><span new="" roman="" style="font-family:" times=""><span style="color:black">. </span></span></span><b><span lang="AR-SA" style="font-size:12.0pt"><span new="" roman="" style="font-family:" times=""><span style="color:black">‎</span></span></span></b><span style="font-size:12.0pt"><span new="" roman="" style="font-family:" times=""><span style="color:black">In addition</span></span></span><b><span lang="AR-SA" style="font-size:12.0pt"><span new="" roman="" style="font-family:" times=""><span style="color:black">‎</span></span></span></b><span style="font-size:12.0pt"><span new="" roman="" style="font-family:" times=""><span style="color:black">, the enzyme-linked immunosorbent assay (ELISA) </span></span></span><b><span lang="AR-SA" style="font-size:12.0pt"><span new="" roman="" style="font-family:" times=""><span style="color:black">‎‏</span></span></span></b><span style="font-size:12.0pt"><span new="" roman="" style="font-family:" times=""><span style="color:black">method was used to determine the levels of </span></span></span><b><span lang="AR-SA" style="font-size:12.0pt"><span new="" roman="" style="font-family:" times=""><span style="color:black">‎</span></span></span></b> <span style="font-size:12.0pt"><span new="" roman="" style="font-family:" times=""><span style="color:black">type І </span></span></span><b><span dir="RTL" lang="AR-SA" style="font-size:12.0pt"><span new="" roman="" style="font-family:" times=""><span style="color:black">‏</span></span></span></b><span style="font-size:12.0pt"><span new="" roman="" style="font-family:" times=""><span style="color:black">and ІІІ collagen and matrix metalloproteinase </span></span></span><b><span dir="RTL" lang="AR-SA" style="font-size:12.0pt"><span new="" roman="" style="font-family:" times=""><span style="color:black">‏</span></span></span></b><b><span lang="AR-SA" style="font-size:12.0pt"><span new="" roman="" style="font-family:" times=""><span style="color:black">‎</span></span></span></b><span style="font-size:12.0pt"><span new="" roman="" style="font-family:" times=""><span style="color:black">1 (MMP1) in scar tissues.<br>
<b><i></i></b></span></span></span></span></span></span></span></span></span><br>
<span style="font-size:10pt"><span style="text-justify:kashida"><span style="text-kashida:0%"><span style="line-height:normal"><span style="tab-stops:396.55pt"><span style="font-family:Calibri,sans-serif"><b><i><span style="font-size:12.0pt"><span new="" roman="" style="font-family:" times=""><span style="color:black">Results:</span></span></span></i></b><span style="font-size:12.0pt"><span new="" roman="" style="font-family:" times=""><span style="color:black"> CH improved abnormal scarring at concentrations of 1.25 and 2.5 mg/ml and significantly (P<0.001) reduced the SEI and ETI. The levels of collagen type І and type ІІІ, and total collagen deposition were significantly (P<0.05) decreased in scar tissues of CH treated groups and no significant effect on MMP1 levels.</span></span></span></span></span></span></span></span></span><br>
<br>
<span style="font-size:10pt"><span style="text-justify:kashida"><span style="text-kashida:0%"><span style="line-height:normal"><span style="tab-stops:396.55pt"><span style="font-family:Calibri,sans-serif"><b><span style="font-size:12.0pt"><span new="" roman="" style="font-family:" times=""><span style="color:black">Conclusion: </span></span></span></b><span style="font-size:12.0pt"><span new="" roman="" style="font-family:" times=""><span style="color:black">Our findings demonstrated that CH has the potential for the treatment of HSs.</span></span></span></span></span></span></span></span></span></span></div>
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Catechin, Collagen, Hypertrophic scar, Rabbit, Wound healing.
13
22
http://rbmb.net/browse.php?a_code=A-10-1448-1&slc_lang=en&sid=1
Sina
Goudarzi Afshar
100319475328460020272
100319475328460020272
No
Department of Pharmacology &Toxicology, School of Pharmacy, Hamadan University of Medical Sciences, Hamadan, Iran.
Pari
Tamri
p.tamri@umsha.ac.ir
100319475328460020273
100319475328460020273
Yes
Department of Pharmacology &Toxicology, School of Pharmacy, Hamadan University of Medical Sciences, Hamadan, Iran.
Alireza
Nourian
100319475328460020274
100319475328460020274
No
Department of Laboratory Sciences, Faculty of Para-Veterinary Sciences, Bu-Ali Sina University, Hamadan, Iran.
Ayoub
Mahmoudi
100319475328460020275
100319475328460020275
No
Department of Pharmacology &Toxicology, School of Pharmacy, Hamadan University of Medical Sciences, Hamadan, Iran.