Site is under construction

en Evaluate the Serum of Irisin, Omentin-1, and Oxidative Status in Males with Prostatic Cancer بیوشیمی Biochemistry مقالات اصلی Original Article <div style="text-align: justify;">Background: Prostate cancer is a classic public health problem in males and has broadly different levels of mortality and morbidity. As an endocrine gland, adipose tissue synthesizes and secretes a variety of bioactive peptides, such as irisin and omentin-1. Adipokines and oxidative stress potentially contribute to the proliferation of prostatic carcinoma cells. The relationship between irisin, omentin-1, and oxidative stress has not been widely investigated in prostate cancer. Therefore, the present research assessed whether there is a significant correlation between irisin and omentin-1 levels and oxidative status in prostate cancer individuals. Methods: The present research recruited 40 individuals diagnosed with prostate cancer and 40 healthy individuals for comparative purposes. All individuals underwent demographics, biochemicals, and serum adipokines (irisin and omentin-1) data analysis. Results: The means of total prostate-specific antigen (43.3±20.5 vs. 2.5±1.2) and free prostate-specific antigen (2.1±1.4 vs. 0.08±0.02) were highly significant increases in the prostate cancer patients than in the healthy individuals. Furthermore, the means of omentin-1 (31.6±12.8 vs. 23.5±14.1) and total oxidant stress (22.4±10.6 vs. 9.1±3.6) were highly significant increases in patients with prostate cancer than in healthy individuals. In contrast, the means of irisin (343.5±240.2 vs. 716.4±142.3) and total antioxidant capacity (2.2±1.2 vs. 3.3±1.3) were highly significant decreases in patients with prostate cancer than in healthy individuals. No significant relationship was demonstrated between all parameters in the two groups under study. Conclusion: The study findings indicate that irisin and omentin-1 could serve as biomarkers for predicting prostate cancer.</div> FNDC5 protein, ITLN1 protein, Oxidative Stress, Prostatic Neoplasms. 23 30 http://rbmb.net/browse.php?a_code=A-10-476-4&slc_lang=en&sid=1 Malik Musa Sultan 100319475328460020276 100319475328460020276 No College of Science, Mustansiriyah University, Palestine Street, Baghdad, Iraq. Talib Hussein Abdullah 100319475328460020277 100319475328460020277 No College of Science, Mustansiriyah University, Palestine Street, Baghdad, Iraq. Mohammed Abbas Abdullah 100319475328460020278 100319475328460020278 No College of Science, Mustansiriyah University, Palestine Street, Baghdad, Iraq. Waleed Al-Darkazali 100319475328460020279 100319475328460020279 No College of Science, Mustansiriyah University, Palestine Street, Baghdad, Iraq. Nazar Sattar Harbi 100319475328460020280 100319475328460020280 Yes College of Science, Mustansiriyah University, Palestine Street, Baghdad, Iraq.