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en Protocatechuic Acid Protects Mice Against Non-Alcoholic Fatty Liver Disease by Attenuating Oxidative Stress and Improving Lipid Profile بیوشیمی Biochemistry مقالات اصلی Original Article <div style="text-align: justify;">Background: Non-alcoholic fatty liver disease (NAFLD) is a general term encompassing many conditions from simple fatty liver to cirrhosis and hepatocellular carcinoma. In this research, we aimed to investigate the effect of the antioxidant protocatechuic acid (PCA) in preventing the development of fatty liver induced by high-fat diet (HFD) in male mice. Methods: Mice (NMRI) were randomly divided into five groups. The groups were as follows: the control received the standard diet, HFD received 20 ml/kg of HFD, HFD containing PCA received HFD containing 200 mg/kg/20 ml of PCA, HFD containing fenofibrate (FENO) received HFD containing 150 mg/kg/20 ml of FENO, and PCA received 200 mg/kg/20 ml of PCA alone for six weeks. Mice were anesthetized after overnight fasting on the 43rd day, and the blood sample was collected from their hearts. The levels of serum, antioxidants and pro-inflammatory factors were measured, and histological studies were performed. Results: The results showed that HFD containing PCA decreased liver enzymes, cholesterol (Chol), and thiobarbituric acid reactive substances (TBARS) levels and increased high-density lipoprotein (HDL), and total thiol levels in the liver compared to the HFD group alone (P<0.001). The histopathological examinations of the liver tissue confirmed the biochemical results. High-fat diet (HFD) containing PCA showed no significant effect on the levels of triglyceride (TG), low-density lipoprotein (LDL), catalase, and superoxide dismutase (SOD). The histopathological examinations of the liver tissue confirmed the biochemical results. Conclusion: The findings of this study demonstrated that PCA is reasonably effective in preventing NAFLD in mice.</div> High-fat diet, Mice, Non-alcoholic fatty liver, Oxidative stress, Protocatechuic acid. 218 230 http://rbmb.net/browse.php?a_code=A-10-1502-1&slc_lang=en&sid=1 Zeinab Zeinalian Boroujeni 100319475328460020408 100319475328460020408 No Medicinal Plant Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran & Department of Toxicology, Faculty of Pharmacy, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran. Layasadat Khorsandi 100319475328460020409 100319475328460020409 No Cellular and Molecular Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran. Leila Zeidooni 100319475328460020410 100319475328460020410 No Department of Toxicology, Faculty of Pharmacy, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran & Student Research Committee, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran. Mahdieh Sadat Badiee 100319475328460020411 100319475328460020411 No Department of Toxicology, Faculty of Pharmacy, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran & Student Research Committee, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran. Mohammad Javad Khodayar khodayar-mj@ajums.ac.ir 100319475328460020412 100319475328460020412 Yes Department of Toxicology, Faculty of Pharmacy, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran & Toxicology Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.