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Reports of Biochemistry and Molecular Biology
rbmb.net
Basic Sciences
http://rbmb.net
1
admin
2322-3480
2322-3480
10.61882/rbmb
en
jalali
1396
7
1
gregorian
2017
10
1
6
1
online
1
fulltext
en
A Description of Reference Ranges for Organic Acids in Urine Samples from A Pediatric Population in Iran
تخصصي
Special
مقالات اصلی
Original Article
<p style="text-align: justify;"><strong><em>Background:</em></strong> Organic acids refer to a family of compounds that are intermediates in a variety of metabolic pathways. Many organic acids are present in urine from clinically normal individuals. Elevated levels of urine organic acids cause to the organic acidurias, disorders in which some metabolic pathways in organic acid metabolism are blocked. The present work identified major and minor urinary acidic metabolites in normal subjects, and their quantitative ranges in a pediatric population of Iran.</p>
<p style="text-align: justify;"><strong><em>Methods: </em></strong>Two hundred and fifty-one healthy subjects, including 132 males and 119 females, from 2 days to 15 years of age were enrolled. Urinary organic acids were extracted from urine with organic solvents and identified and quantified by gas chromatography-mass spectrometry.</p>
<p style="text-align: justify;"><strong><em>Results: </em></strong>The results provide a foundation on which to check results for patients with potentially abnormal organic acidurias. By this method 98 organic acids were identified in a pediatric population of Iran.</p>
<p style="text-align: justify;"><strong><em>Conclusions: </em></strong>The present work identifies and quantifies major and minor urinary metabolites excreted by normal subjects. We also analyzed urine from 30 patients with organic acid metabolism abnormalities and compared the concentrations of specific organic acids with those from urines of normal individuals.</p>
Gas chromatography/mass spectrometry, Iran population, Normal individuals, Urine organic acid analysis, Urine organic acids range
40
50
http://rbmb.net/browse.php?a_code=A-10-1-84&slc_lang=en&sid=1
Fatemeh
Keyfi
10031947532846005550
10031947532846005550
No
Varastegan Institute for Medical Sciences, Mashhad, Iran - Pardis Clinical and Genetic Laboratory, Mashhad, Iran.
Zoltan
Lukacs
10031947532846005551
10031947532846005551
No
Metabolic Laboratory, Hamburg University of Medical Center, Hamburg, Germany.
Abdolreza
Varasteh
varasteha@mums.ac.ir
10031947532846005552
10031947532846005552
Yes
Immunobiochemistry Lab, Allergy Research Center, Mashhad University of Medical Sciences, Mashhad, Iran - Varastegan Institute for Medical Sciences, Mashhad, Iran - Pardis Clinical and Genetic Laboratory, Mashhad, Iran.