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'); Reports of Biochemistry and Molecular Biology rbmb.net Basic Sciences http://rbmb.net 1 admin 2322-3480 2322-3480 10.61882/rbmb en jalali 1403 10 1 gregorian 2025 1 1 13 4 online 1 fulltext
en The Inhibitory Effect of Aqueous Ginger Extract on the Genotoxicity of Dexamethasone in Male Albino Mice زیست شناسی ملکولی Molecular Biology مقالات اصلی Original Article <div style="text-align: justify;"><span style="font-size:10pt"><span style="text-justify:kashida"><span style="text-kashida:0%"><span style="line-height:normal"><span style="tab-stops:396.55pt"><span style="font-family:Calibri,sans-serif"><b><i><span lang="EN-GB" style="font-size:12.0pt"><span new="" roman="" style="font-family:" times=""><span style="color:black"><span style="letter-spacing:-.4pt">Background:</span></span></span></span></i></b> <span style="font-size:12.0pt"><span new="" roman="" style="font-family:" times=""><span style="color:black"><span style="letter-spacing:-.2pt">Many natural substances generated from plant crude extracts have recently been shown to protect against the harmful effects of a variety of pollutants. Ginger (<i>Zingiber officinalis</i>) is a widely used spice and medicinal herb.</span></span></span></span></span></span></span></span></span></span><br> <br> <span style="font-size:10pt"><span style="text-justify:kashida"><span style="text-kashida:0%"><span style="line-height:normal"><span style="tab-stops:396.55pt"><span style="font-family:Calibri,sans-serif"><b><i><span style="font-size:12.0pt"><span new="" roman="" style="font-family:" times=""><span style="color:black"><span style="letter-spacing:-.2pt">Methods</span></span></span></span></i></b><span style="font-size:12.0pt"><span new="" roman="" style="font-family:" times=""><span style="color:black"><span style="letter-spacing:-.2pt">: To study the effect of aqueous ginger extract in inhibiting the genotoxicity of dexamethasone, we gave the first group dexamethasone (0.4 mg/kg) only. The second group was treated with an aqueous extract of ginger (50 mg/kg) only. The third group was treated with an aqueous extract of ginger followed by dexamethasone with a two-hour interval between doses. The last group was treated with dexamethasone and an aqueous ginger extract simultaneously. To perform genetic tests, we used mitotic index, chromosomal aberrations, and micronuclei tests.</span></span></span></span></span></span></span></span></span></span><br> <br> <span style="font-size:10pt"><span style="text-justify:kashida"><span style="text-kashida:0%"><span style="line-height:normal"><span style="tab-stops:396.55pt"><span style="font-family:Calibri,sans-serif"><b><i><span style="font-size:12.0pt"><span new="" roman="" style="font-family:" times=""><span style="color:black"><span style="letter-spacing:-.2pt">Results</span></span></span></span></i></b><b><span style="font-size:12.0pt"><span new="" roman="" style="font-family:" times=""><span style="color:black"><span style="letter-spacing:-.2pt">:</span></span></span></span></b><span style="font-size:12.0pt"><span new="" roman="" style="font-family:" times=""><span style="color:black"><span style="letter-spacing:-.2pt"> After the treatment with dexamethasone, chromosome aberration and micronuclei formation were induced; however, after treatment with an aqueous extract of ginger, chromosomal aberrations and micronuclei were significantly reduced in male mice. The aqueous extract of ginger did not exhibit cytotoxicity and showed high inhibitory efficiency against the toxicity and mutagenicity of dexamethasone.</span></span></span></span></span></span></span></span></span></span><br> <br> <span style="font-size:10pt"><span style="text-justify:kashida"><span style="text-kashida:0%"><span style="line-height:normal"><span style="tab-stops:396.55pt"><span style="font-family:Calibri,sans-serif"><b><i><span style="font-size:12.0pt"><span new="" roman="" style="font-family:" times=""><span style="color:black"><span style="letter-spacing:-.2pt">Conclusion</span></span></span></span></i></b><b><span style="font-size:12.0pt"><span new="" roman="" style="font-family:" times=""><span style="color:black"><span style="letter-spacing:-.2pt">:</span></span></span></span></b><span style="font-size:12.0pt"><span new="" roman="" style="font-family:" times=""><span style="color:black"><span style="letter-spacing:-.2pt"> The aqueous extract of ginger plays a promising role in protecting somatic cells from the cytogenetic effects of dexamethasone, and it reduces chromosomal aberrations and micronuclei in male albino mice.</span></span></span></span></span></span></span></span></span></span></div> Chromosome Aberrations, Dexamethasone, Mitotic Index, Micronucleus, Zingiber officinale. 466 473 http://rbmb.net/browse.php?a_code=A-10-1655-1&slc_lang=en&sid=1 Aseel Raheem Al-Aamiri aseel.alaamiri@qu.edu.iq 100319475328460021698 100319475328460021698 Yes Department of Biology, College of Education, Al-Qadisiyah University, Al-Qadisiyah, Iraq.