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en Investigation of Genetic Variations in APLN and APLNR Genes and Their Potential Role in Cardiovascular Diseases بیوشیمی Biochemistry مقالات اصلی Original Article <div class="WordSection1"> <div style="text-align: justify;">Background: Apelin is a naturally produced ligand for G protein-linked receptors derived from a 77-amino acid pre-propeptide. The effect of apelin on the development of cardiovascular diseases and the relationship between the apelin gene and the apelin receptor. Methods: The case-control study included 100 participants of people suffering from cardiovascular diseases. Samples were collected from patients hospitalized at the Nasiriyah Heart Center between November 10, 2023, and February 15, 2024. The study also included 50 healthy people who did not suffer from cardiovascular disease. The lipid profile was measured by spectrophotometer, and the Apelin level was measured by enzyme-linked immunosorbent assay. Four single nucleotide polymorphisms for Apelin (APLN) and Apelin receptor (APLNR) were chosen, and Sanger sequencing was used to genotype them accurately. Results: The findings indicated that there was no statistically significant difference in age between the two groups. Upon comparing the age demographics of the two groups in the study, the results indicated a lack of statistical significance in the levels of APLN or the lipid profile, despite the case group exhibiting markedly elevated Apelin and lipid levels compared to the control group. After multiple test adjustments (P < 0.05), neither the APLN rs2235310T allele nor the APLNR rs9943582 allele demonstrated an association with an elevated risk of coronary heart disease. Conclusion: The investigation revealed no significant age variations or genetic correlations associated with CHD risk. However, rather than age or genetic differences, elevated apelin and cholesterol levels in the case group indicate these factors as primary contributors to cardiovascular risk.  </div> </div> <div style="text-align: justify;"><div aria-label="Page Break" class="cke_pagebreak" contenteditable="false" data-cke-display-name="pagebreak" data-cke-pagebreak="1" style="page-break-after:always" title="Page Break"></div></div> Apelin Receptors, Cardiac, Lipid Metabolism, Polymorphism, Risk factors. 525 539 http://rbmb.net/browse.php?a_code=A-10-1683-1&slc_lang=en&sid=1 Nabaa Azhar Abdulmuttaleb 100319475328460021682 100319475328460021682 No Department of Clinical Laboratories, College of Applied Medical Sciences, University of Kerbala, Iraq. Abdelhameed Abdelkhaliq Oliwi Nasir 100319475328460021683 100319475328460021683 No Al Iraqia University, College of Dentistry, Iraq. Sami awad Alkubaisy 100319475328460021684 100319475328460021684 No Center of Desert Studies, University of Anbar, Iraq. Osama Akram Mohsein osamaakram889@gmail.com. 100319475328460021685 100319475328460021685 Yes Department of Medical Laboratory Techniques, Mazaya University College, Thi-Qar, Iraq & Thi-Qar Health Directorate, Al Habbobi Teaching Hospital, Thi-Qar, Iraq.