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en A Survey on the Role of Interleukin-10 in Breast Cancer: A Narrative بیوشیمی Biochemistry مقالات مروری Review <div style="text-align: justify;">Interleukin (IL)-10, a multifunctional immune-regulatory cytokine with both immunosuppressive and anti-angiogenic functions, is produced by immune cells including macrophages, T lymphocytes, and natural killer cells. Among other effects, IL-10 promotes tumor cell proliferation and metastasis via immunosuppression. Interleukin-10-mediated immunosuppression is aided by synthesis of tumor necrosis factor, IL-1, IL-12, and chemokines, and down regulation of the surface co-stimulatory molecules CD80 and CD86 on tumors. Interleukin-10 also promotes IL-6 expression and synthesis, which causes cell proliferation via B cell lymphoma-2 (Bcl-2) upregulation and changes the proliferation/apoptosis equivalence toward neoplastic cell proliferation. Moreover, IL-10 inhibits tumorigenesis via down-regulation of VEGF, IL-1b, TNF-α, IL-6, and MMP-9. Interleukin-10 also inhibits nuclear factor-κB (NF-κB) translocation. Interleukin-10 has been reported to have both tumor-promoting and -inhibiting properties. It seems that IL-10 agonists and antagonists may have therapeutic effects via different mechanisms. Moreover, IL-10 gene polymorphisms may determine breast cancer susceptibility.</div> Breast cancer, Cytokine, IL-10 30 37 http://rbmb.net/browse.php?a_code=A-10-47-4&slc_lang=en&sid=1 Elnaz Sheikhpour 10031947532846006357 10031947532846006357 No Hematology and Oncology Research Center, Shahid Sadoughi University of Medical Science, Yazd, Iran. Parisa Noorbakhsh parisanourbakhash@yahoo.com 10031947532846006358 10031947532846006358 Yes Department of Immunology, School of Medicine, Arak university of Medical Sciences, Arak, Iran. Elnaz Foroughi 10031947532846006359 10031947532846006359 No Department of Pediatric Dentistry, Arak university of Medical Sciences, Arak, Iran. Soudabeh Farahnak 10031947532846006360 10031947532846006360 No Department of Endodontic, Arak university of Medical Sciences, Arak, Iran. Rezvan Nasiri 10031947532846006361 10031947532846006361 No Department of Restorative and Esthetic, Arak University of Medical Sciences, Arak, Iran. Hossein Neamatzadeh 10031947532846006362 10031947532846006362 No Mother and Newborn Health Research Center, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.