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en Comparative Analysis of Curcumin and Metformin Effects on the Kidney in a Model of Unilateral Nephrectomy and Ischemia-Reperfusion Injury بیوشیمی Biochemistry مقالات اصلی Original Article <div class="WordSection1"> <div style="text-align: justify;">Background: Unilateral nephrectomy and renal ischemia-reperfusion injury (I/R) are causes of acute kidney injury that can cause renal dysfunction, decreased glomerular filtration rate, impaired homeostasis, and increased mortality. This study aimed to evaluate the combined effects of curcumin (Cur) and metformin (Met), both protective antioxidants, on renal tissue structure and Neutrophil gelatinase-associated lipocalin (Ngal) and Kidney injury molecule 1 (Kim-1) genes expression levels in rats undergoing unilateral nephrectomy and ischemia/reperfusion. Methods: In this experimental study, 40 male rats were randomly divided into five groups. The animals underwent unilateral nephrectomy and ischemia/reperfusion and were then treated with curcumin and metformin or both for 14 days. Subsequently, histopathological and morphometric analyses were performed, and Ngal and Kim-1 gene expression levels were evaluated using real-time PCR. Results: Histopathological damage, expression levels of blood urea nitrogen (BUN), creatinine (Cr), blood biochemical parameters and oxidative stress and expression levels of Ngal and Kim-1 genes were significantly reduced in the patient group that received metformin and curcumin simultaneously. However, total antioxidant capacity (TAC) was increased in the patient group that received curcumin + metformin. Morphometric parameters also improved in this group. Conclusion: The results showed that the combination therapy with curcumin and metformin effectively protected the kidneys against unilateral nephrectomy and I/R injury. </div> <div align="center" style="text-align:center"> <hr align="center" noshade="noshade" size="2" style="color:#0f243e" width="100%" ></div> </div> <div style="text-align: justify;"><div aria-label="Page Break" class="cke_pagebreak" contenteditable="false" data-cke-display-name="pagebreak" data-cke-pagebreak="1" style="page-break-after:always" title="Page Break"></div></div> Curcuminoid, Ischemia-reperfusion injury, Metformin, Unilateral nephrectomy. 579 589 http://rbmb.net/browse.php?a_code=A-10-1700-1&slc_lang=en&sid=1 Samaneh Karimi 100319475328460021506 100319475328460021506 No Department of Anatomical Sciences, School of Medicine, Abadan University of Medical Sciences, Abadan, Iran. Farhad Koohpeyma 100319475328460021507 100319475328460021507 No Student Research Committee, Endocrinology and Metabolism Research Center, Shiraz University of Medical Science, Shiraz, Iran. Layasadat Khorsandi 100319475328460021508 100319475328460021508 No Cellular and Molecular Research Center, Medical Basic Sciences Research Institute, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran & Department of Anatomical Sciences, Faculty of Medicine, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran. Armin Panahi 100319475328460021509 100319475328460021509 No Cellular and Molecular Research Center, Medical Basic Sciences Research Institute, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran. Fatemeh Rezaei-Tazangi 100319475328460021510 100319475328460021510 No Department of Anatomy, Faculty of Medicine, Fasa University of Medical Sciences, Fasa, Iran. Fereshtesadat Fakhredini ffakhredini_aot@yahoo.com 100319475328460021511 100319475328460021511 Yes Cellular and Molecular Research Center, Medical Basic Sciences Research Institute, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran & Department of Anatomical Sciences, Faculty of Medicine, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.