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en Effect of Genistein and L-carnitine and Their Combination on Lipid Profile and Inflammatory Cytokines in Experimental Nephrotic Syndrome زیست شناسی ملکولی Molecular Biology مقالات اصلی Original Article Background: Nephrotic syndrome is a disorder caused by kidney damage that results in severe leakage of protein from blood into urine. Hyperlipidemia is one complication of nephrotic syndrome. L-carnitine and genistein can control cardiovascular diseases by causing changes in lipid metabolism and cytokine production. This study was designed to examine the effects of genistein and L-carnitine on serum lipid and cytokine profiles in experimental nephrotic syndrome. Methods: In this study, 50 male Sprague–Dawley rats were randomly divided into five groups of 10 animals each with similar mean body weights (300±50 g). The five groups were NC (normal-control), PC (patient-control), LC (L-carnitine), G (genistein), and LCG (L-carnitine-genistein). Serum HDL-cholesterol (HDL) LDL-cholesterol (LDL), triglyceride, cholesterol, IL-6, and TNF-α were measured. Statistics were analyzed using SPSS 18.0.  Results: At the end of the study, of the patient groups, HDL was significantly greater in the LC than in the PC or G groups (P<0.001). LDL was significantly less in the G than in the PC, LC, or LCG groups (P<0.001). Interleukin-6 was significantly greater in the PC than in the LC, G, or LCG groups, and significantly greater in the LC than in the G group. (P<0.001), but no significant differences were found for triglyceride, cholesterol, or TNF-α between the patient groups. Conclusions: Genistein had less effect on HDL and triglyceride levels than LC or LCG. Regarding inflammatory cytokines, genistein and L-carnitine had less effect on TNF-α than on IL-6. Genistein, Hyperlipidemia, Interleukin 6, L-carnitine, Nephrotic syndrome, TNF-alpha 1 8 http://rbmb.net/browse.php?a_code=A-10-83-1&slc_lang=en&sid=1 Abbas Yousefinejad yousefinejad.abs@gmail.com 10031947532846006326 10031947532846006326 No Department of Nutrition, School of Public Health, Bushehr University of Medical Sciences, Bushehr, Iran. & Department of Cellular and Molecular Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences, Tehran, Iran. Fereydoon Siassi fereydoun.siassi@gmail.com 10031947532846006327 10031947532846006327 No Department of Community Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences, Tehran, Iran. Mohammad Hassan Javanbakht mhjavan2001@yahoo.com 10031947532846006328 10031947532846006328 No Department of Cellular and Molecular Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences, Tehran, Iran. Hamed Mohammadi mohamadihd@gmail.com 10031947532846006329 10031947532846006329 No Department of Community Nutrition, Student Research Committee, School of Nutrition and Food Science, Isfahan University of Medical Sciences, Isfahan, Iran. Ehsan Ghaedi en7cyrus@gmail.com 10031947532846006330 10031947532846006330 No Cancer, environmental and petroleum pollutant research center, Ahvaz Jundishapur university of Medical sciences, Ahvaz, Iran. Mahnaz Zarei mahnazzareei@yahoo.com 10031947532846006331 10031947532846006331 No Department of Cellular and Molecular Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences, Tehran, Iran. Ehsan Djalali 10031947532846006332 10031947532846006332 No Department of Veterinary, Science and Research Branch of Islamic Azad University, Tehran, Iran. Mahmoud Djalali mjalali87@yahoo.com 10031947532846006333 10031947532846006333 Yes Department of Cellular and Molecular Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences, Tehran, Iran.