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'); Reports of Biochemistry and Molecular Biology rbmb.net Basic Sciences http://rbmb.net 1 admin 2322-3480 2322-3480 10.61882/rbmb en jalali 1404 5 1 gregorian 2025 8 1 14 2 online 1 fulltext
en Anti-apoptotic, Anti-inflammatory, Anti-ulcer Effect of Silver Green Synthesis of Boesenbergia Rotunda Rhizome ایمنی شناسی Immunology مقالات اصلی Original Article <div style="text-align: justify;"><span style="font-size:10pt"><span style="text-justify:kashida"><span style="text-kashida:0%"><span style="line-height:normal"><span style="tab-stops:396.55pt"><span style="font-family:Calibri,sans-serif"><b><i><span lang="EN-GB" style="font-size:12.0pt"><span style="font-family:&quot;Times New Roman&quot;,serif"><span style="color:black"><span style="letter-spacing:-.4pt">Background:</span></span></span></span></i></b> <span style="font-size:12.0pt"><span style="font-family:&quot;Times New Roman&quot;,serif"><span style="color:black"><span style="letter-spacing:-.2pt">Silver nanoparticles (SNPs) synthesized using the aqueous rhizome extract of <i>Boesenbergia rotunda</i> exhibit a wide range of biological activities and have traditionally been used in treating various ailments. The present study aimed to evaluate the gastroprotective effects of biosynthesized SNPs against ethanol-induced acute gastric mucosal injury in rats.</span></span></span></span></span></span></span></span></span></span><br> <br> <span style="font-size:10pt"><span style="text-justify:kashida"><span style="text-kashida:0%"><span style="line-height:normal"><span style="tab-stops:396.55pt"><span style="font-family:Calibri,sans-serif"><b><i><span style="font-size:12.0pt"><span style="font-family:&quot;Times New Roman&quot;,serif"><span style="color:black"><span style="letter-spacing:-.2pt">Methods: </span></span></span></span></i></b><span style="font-size:12.0pt"><span style="font-family:&quot;Times New Roman&quot;,serif"><span style="color:black"><span style="letter-spacing:-.2pt">SNPs were synthesized and characterized using X-ray diffraction (XRD), UV&ndash;Vis spectroscopy, and transmission electron microscopy (TEM).</span></span></span></span></span></span></span></span></span></span><br> <br> <span style="font-size:10pt"><span style="text-justify:kashida"><span style="text-kashida:0%"><span style="line-height:normal"><span style="tab-stops:396.55pt"><span style="font-family:Calibri,sans-serif"><b><i><span style="font-size:12.0pt"><span style="font-family:&quot;Times New Roman&quot;,serif"><span style="color:black"><span style="letter-spacing:-.2pt">Result:</span></span></span></span></i></b><span style="font-size:12.0pt"><span style="font-family:&quot;Times New Roman&quot;,serif"><span style="color:black"><span style="letter-spacing:-.2pt"> Alleviated ethanol-induced gastric lesions, as evidenced by a reduced ulcer index. Ethanol-induced gastric damage was associated with decreased mucus production, lowered gastric pH, and increased ulcerated areas, edema, and inflammatory cell infiltration in the submucosa. Administration of SNPs markedly increased the activities of superoxide dismutase (SOD) and catalase (CAT), and elevated prostaglandin E2 (PGE2) levels, while significantly reducing malondialdehyde (MDA) concentrations in gastric tissue homogenates. SNPs also prevented oxidative stress by inhibiting lipid peroxidation. Furthermore, SNP treatment enhanced periodic acid&ndash;Schiff (PAS) staining of the gastric mucosa, upregulated HSP-70 protein expression, and downregulated Bax protein levels. SNPs also modulated inflammatory cytokines by increasing IL-10 and reducing TNF-&alpha; and IL-6 levels. Acute toxicity testing at a high dose (500 mg/kg) showed no toxicological symptoms in rats.</span></span></span></span></span></span></span></span></span></span><br> <br> <span style="font-size:10pt"><span style="text-justify:kashida"><span style="text-kashida:0%"><span style="line-height:normal"><span style="tab-stops:396.55pt"><span style="font-family:Calibri,sans-serif"><b><i><span style="font-size:12.0pt"><span style="font-family:&quot;Times New Roman&quot;,serif"><span style="color:black"><span style="letter-spacing:-.2pt">Conclusion:</span></span></span></span></i></b><span style="font-size:12.0pt"><span style="font-family:&quot;Times New Roman&quot;,serif"><span style="color:black"><span style="letter-spacing:-.2pt"> The present study demonstrates that <i>Boesenbergia rotunda</i>-derived silver nanoparticles exert significant gastroprotective effects, likely due to their antioxidant properties, stimulation of gastric secretions, enhancement of endogenous antioxidant enzymes (SOD, CAT, PGE2), suppression of lipid peroxidation, upregulation of HSP-70, downregulation of Bax, and modulation of inflammatory cytokines.</span></span></span></span></span></span></span></span></span></span></div> Bax, Boesenbergia rotunda, Histology, HSP 70, Silver nanoparticle, Stomach ulcer. ​​​​​​​ 191 205 http://rbmb.net/browse.php?a_code=A-10-1714-1&slc_lang=en&sid=1 Tola Abdulsattar Faraj tola.faraj@tiu.edu.iq 100319475328460022403 100319475328460022403 Yes 1: Department of Physiology and Microbiology, College of Medicine, Hawler Medical University, Erbil 44001, Kurdistan Region, Iraq & Department of Medical Analysis, Faculty of Applied Science, Tishk International University, Erbil 44001, Kurdistan Region, Iraq.