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en Herniarin Alleviates Sodium Arsenite-Induced Liver Toxicity in Mice by Attenuation of Oxidative Stress and Inflammation بیوشیمی Biochemistry مقالات اصلی Original Article <div class="WordSection1"> <div style="text-align: justify;">Background: Arsenic is a serious threat to human health. Long-term exposure to arsenic has been linked to various harmful health effects, including liver damage. The liver damage caused by arsenic is mainly due to inflammation and oxidative stress. This research was performed to investigate the hepatoprotective effects of herniarin (HER), a coumarin derivative found in many plants, against hepatotoxicity induced by sodium arsenite (SA). Methods: To induce hepatotoxicity, SA at a dose of 10 mg/kg was administered to mice for 30 days. HER at doses of 10, 25, and 50 mg/kg was given to mice for 30 days before SA administration. After completing the study protocol, the animals were euthanized, and blood and liver samples were collected for biochemical assessments. Results: The results showed that SA increased liver enzymes and causes tissue damage, as well as elevated oxidative substances such as substances reactive to thiobarbituric acid in the liver, while simultaneously leading to a decrease in total thiol reserves and decreases in antioxidant enzymes such as catalase, superoxide dismutase, and glutathione peroxidase. Western blot analysis showed decreased protein expression of Nrf2, NQO1, and HO-1. Conclusions: Pretreatment with HER ameliorated SA-associated liver injury in mice. HER reduced hepatotoxicity and oxidative damage caused by SA and increased antioxidant factors.</div> </div> <div style="text-align: justify;"><div aria-label="Page Break" class="cke_pagebreak" contenteditable="false" data-cke-display-name="pagebreak" data-cke-pagebreak="1" style="page-break-after:always" title="Page Break"></div></div> Arsenic, Hepatotoxicity, Herniarin, Nrf2, Oxidative stress. 181 190 http://rbmb.net/browse.php?a_code=A-10-1293-2&slc_lang=en&sid=1 Faride Alvandi 100319475328460022398 100319475328460022398 No Department of Toxicology, Faculty of Pharmacy, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran & Toxicology Research Center, Medical Basic Sciences Research Institute, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran. Mehrnoush Matin 100319475328460022399 100319475328460022399 No Department of Toxicology, Faculty of Pharmacy, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran & Toxicology Research Center, Medical Basic Sciences Research Institute, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran & Student Research Committee, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran. Maryam Salehcheh 100319475328460022400 100319475328460022400 No Department of Toxicology, Faculty of Pharmacy, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, IranDepartment of Toxicology, Faculty of Pharmacy, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran & Toxicology Research Center, Medical Basic Sciences Research Institute, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran. Layasadat Khorsandi 100319475328460022401 100319475328460022401 No Cellular and Molecular Research Center, Medical Basic Sciences Research Institute, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran. Mehrnoosh Moosavi mehrnoosh.moosavi59@gmail.com 100319475328460022402 100319475328460022402 Yes Department of Toxicology, Faculty of Pharmacy, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran & Toxicology Research Center, Medical Basic Sciences Research Institute, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.