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en Lack of Association between Interleukin 23R (IL-23R) rs10889677 Polymorphism and Inflammatory Bowel Disease Susceptibility In an Iranian Population زیست شناسی ملکولی Molecular Biology مقالات اصلی Original Article <div style="text-align: justify;">Background: Inflammatory bowel diseases (IBDs), which include ulcerative colitis (UC) and Crohn’s disease (CD), are inflammatory disorders that affect the gastrointestinal tract. A combination of inflammatory cytokines has an important role in IBD development. Genome-wide association studies have shown that polymorphisms in the interleukin-23R gene (IL-23R) increase susceptibility to IBD. The aim of this study was to investigate the IL-23R 3' UTR SNP to determine a potential association between genotype distribution and IBD. Methods: The case group included 102 IBD patients and the control group included 107 healthy individuals. IL-23R polymorphisms rs10889677 were genotyped using PCR-RFLP analysis. RFLP results were confirmed by direct sequencing.  Results: The allele and genotype frequencies in patients and controls were evaluated and compared, and no significant association between this functional rs10889677 polymorphism and risk of IBD was observed (P=0.587; adjusted OR: 0.89; 95% CI: 0.597-1.339). We also found no significant association between CD (14.71%) and UC (85.29%) patients in allele or genotype levels (P>0.05). Conclusions: Our results suggest that the rs10889677 A>C polymorphism is not a potential prognostic marker in Iranian patients with IBD.  </div> Crohn’s disease, Inflammatory bowel diseases, Interleukin 23 receptor, rs10889677, Ulcerative colitis 16 22 http://rbmb.net/browse.php?a_code=A-10-94-1&slc_lang=en&sid=1 Sara Karimkhani ms.jili@yahoo.com 10031947532846006340 10031947532846006340 No Basic and Molecular Epidemiology of Gastrointestinal Disorders Research Center, Research Institute for Gastroenterology and Liver Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran. Vahid Chaleshi chaleshi@gmail.com 10031947532846006341 10031947532846006341 No Basic and Molecular Epidemiology of Gastrointestinal Disorders Research Center, Research Institute for Gastroenterology and Liver Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran. Hedie Balaii hedie.baalaei@gmail.com 10031947532846006342 10031947532846006342 No Basic and Molecular Epidemiology of Gastrointestinal Disorders Research Center, Research Institute for Gastroenterology and Liver Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran. Peyman Tarban peymantarban@yahoo.com 10031947532846006343 10031947532846006343 No Basic and Molecular Epidemiology of Gastrointestinal Disorders Research Center, Research Institute for Gastroenterology and Liver Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran. Mahyar Nourian mahyarnourian1369@gmail.com 10031947532846006344 10031947532846006344 No Basic and Molecular Epidemiology of Gastrointestinal Disorders Research Center, Research Institute for Gastroenterology and Liver Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran. Shiva Irani shi_irani@yahoo.com 10031947532846006345 10031947532846006345 No Department of Biology, Science and Research Branch, Islamic Azad University, Tehran, Iran. Shabnam Shahrokh shabnamshahrokh@gmail.com 10031947532846006346 10031947532846006346 No Gastroenterology and Liver Diseases Research Center, Research Institute for Gastroenterology and Liver Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran. Hamid Asadzadeh Aghdaei hamid.assadzadeh@gmail.com 10031947532846006347 10031947532846006347 No Basic and Molecular Epidemiology of Gastrointestinal Disorders Research Center, Research Institute for Gastroenterology and Liver Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran. Amir Houshang Mohammad Alizadeh ahmaliver@yahoo.com 10031947532846006348 10031947532846006348 No Gastroenterology and Liver Diseases Research Center, Research Institute for Gastroenterology and Liver Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran. Mohsen Norouzinia norouzinia@gmail.com 10031947532846006349 10031947532846006349 Yes Gastroenterology and Liver Diseases Research Center, Research Institute for Gastroenterology and Liver Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran. Mohammad Reza Zali nnzali@hotmail.com 10031947532846006350 10031947532846006350 No Gastroenterology and Liver Diseases Research Center, Research Institute for Gastroenterology and Liver Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran.