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en Oral Administration of Zataria multiflora Extract Decreases IL-17 Expression in Perennial Allergic Rhinitis ایمنی شناسی Immunology مقالات اصلی Original Article Background: Rhinitis, which occurs most commonly as allergic rhinitis and affects 20% of the world’s population, is a major health care burden causing significant morbidity. Considering the high prevalence of allergic rhinitis and anti-inflammatory effects of thyme, a favorite condiment, we performed a randomized clinical trial to determine whether thyme can relieve allergic rhinitis symptoms and affect the expression of TH17- and T-regulatory cell- (Treg) related cytokines IL-17, TGF-β, FOXP3, and IL-10. Methods: Thirty patients with allergic rhinitis symptoms and positive skin prick test for common aero allergens were randomly assigned to experimental or control groups. The experimental group received thyme or Zataria multiflora (ZM) extracts and the control group received placebo for two months. Expression of IL-17, TGF-b, FOXP3, and IL-10 was evaluated in all subjects by real-time PCR before and after intervention. Results: After treatment IL-17 expression was significantly less in the ZM group than in controls (p<0.05), while TGF-β, FOXP3, and IL-10, expression were not significantly changed. Conclusions: Given the significant effect of thyme in reducing symptoms of allergic rhinitis and decrease IL-17 gene expression and because allergic rhinitis is a multifactorial disease, the administration of thyme extract along with conventional treatments may benefit allergic rhinitis sufferers. Allergic rhinitis, IL-17, Herbal product, Thyme, Zataria multiflora. 203 207 http://rbmb.net/browse.php?a_code=A-10-41-2&slc_lang=en&sid=1 Nazila Ariaee ariaeen931@mums.ac.ir 10031947532846007665 10031947532846007665 No Allergy research Center, Mashhad University of Medical sciences, Mashhad Iran. Jalal Ghorbani ghornani.jalal@yahoo.com 10031947532846007666 10031947532846007666 No Allergy research Center, Mashhad University of Medical sciences, Mashhad Iran. Maryam Panahi panahim941@mums.ac.ir 10031947532846007667 10031947532846007667 No Allergy research Center, Mashhad University of Medical sciences, Mashhad Iran. Mojgan Mohamadi Mohammdimzh@mums.ac.ir 10031947532846007668 10031947532846007668 No Allergy research Center, Mashhad University of Medical sciences, Mashhad Iran. Javad Asili asilij@mums.ac.ir 10031947532846007669 10031947532846007669 No Department of Pharmacognosy, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran. Alireza Ranjbar ranjbara@mums.ac.ir 10031947532846007670 10031947532846007670 No Interventional Allergology and Immunology, University of Colgan, Bonn, Germany. Reza Farid Hoseini faridr@mums.ac.ir 10031947532846007671 10031947532846007671 No Allergy research Center, Mashhad University of Medical sciences, Mashhad Iran. Farahzad Jabbari Jabbarif@mums.ac.ir 10031947532846007672 10031947532846007672 Yes Allergy research Center, Mashhad University of Medical sciences, Mashhad Iran.