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en The Influence of Gamma Radiation Processing on the Allergenicity of Main Pistachio Allergens ایمنی شناسی Immunology مقالات اصلی Original Article <div style="text-align: justify;">Background: Gamma irradiation is a form of processing with an array of applications in medical sciences such as microbial decontamination, viruses inactivation, cervical carcinoma and breast cancer treatment. One of the ways in which gamma irradiation has the potential to be used is in reducing the allergenicity of food allergens. Methods: In the present study, pistachios were irradiated with either a 1, 10, or 100 kGy dose of gamma irradiation. The binding rate of mice and human antibodies to the allergens of the pistachio extracts were examined via Western blot analysis. Results: Our findings show an inverse dose-response relationship between the binding rate of antibodies to the pistachio allergens and the gamma irradiation dose. Despite these promising findings, the results of our sensory evaluation indicate that gamma irradiation causes undesirable changes to the sensory characteristics of pistachios, especially at the dose of 100 kGy. Conclusions: Gamma irradiation appears to be an effective method in reducing the allergenicity of pistachios. Thus, this form of processing has the potential to prevent adverse allergic reactions to the major pistachio allergens in sensitized subjects. However, further research must be dedicated to examining the dose sufficient in reducing allergencity, while maintaining adequate sensory quality for satisfactory consumption.  </div> Allergenicity, Gamma irradiation, Pistachio. 150 155 http://rbmb.net/browse.php?a_code=A-10-119-1&slc_lang=en&sid=1 Vahid Yaghoubi Naei vahid.yaghoobi.68@gmail.com 100319475328460017041 100319475328460017041 Yes Immunology Research Center, Bu-Ali Research Institute, University of Medical Sciences, Mashhad, Iran. Mojtaba Sankian sankianm@mums.ac.ir 100319475328460017042 100319475328460017042 No Immunology Research Center, Bu-Ali Research Institute, University of Medical Sciences, Mashhad, Iran. Malihe Moghadam moghadamm@mums.ac.ir 100319475328460017043 100319475328460017043 No Immunology Research Center, Bu-Ali Research Institute, University of Medical Sciences, Mashhad, Iran. Narges Farshidi farshidin921@mums.ac.ir 100319475328460017044 100319475328460017044 No Immunology Research Center, Bu-Ali Research Institute, University of Medical Sciences, Mashhad, Iran. Seyed Hasan Ayati 100319475328460017045 100319475328460017045 No Immunology Research Center, Bu-Ali Research Institute, University of Medical Sciences, Mashhad, Iran. Fatemeh Hamid 100319475328460017046 100319475328460017046 No Department of Medical Laboratory, Varastegan Institute for Medical Sciences, Mashhad, Iran. Abdol-Reza Varasteh Varasteha@varastegan.ac.ir 100319475328460017047 100319475328460017047 No Immunology Research Center, Bu-Ali Research Institute, University of Medical Sciences, Mashhad, Iran.