Reports of Biochemistry and Molecular Biology
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Basic Sciences
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2322-3480
2322-3480
10.61186/rbmb
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jalali
1397
10
1
gregorian
2019
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Overexpression of Lactate Dehydrogenase in the Saliva and Tissues of Patients with Head and Neck Squamous Cell Carcinoma
زیست شناسی ملکولی
Molecular Biology
مقالات اصلی
Original Article
<div style="text-align: justify;"><strong><em>Background:</em></strong> Head and neck squamous cell carcinoma (HNSCC) is the sixth most common malignancy that is associated with high morbidity and mortality. Salivary lactate dehydrogenase (LDH concentration), as an expression of cellular necrosis, may be a special marker of lesions that occur with changes in the integrity of the oral mucosa. This study was performed to determine the accuracy of salivary LDH as a clinical marker for HNSCC detection and to investigate the relationship between salivary LDH levels and tissue tumor detection.<br>
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<strong><em>Methods:</em></strong> The case group consisted of 44 HNSCC patients and the control group consisted of 44 healthy subjects. The stage and grade of HNSCC were determined, and the LDH levels in collected saliva samples were measured in all subjects. The expression of LDH in tumors and healthy tissue margins was evaluated via immunohistochemistry.<br>
<br>
<strong><em>Results:</em></strong> The expression of LDH in the saliva of patients with HNSCC is significantly higher than that in the saliva of the healthy control group. The expression of salivary LDH in patients with oral squamous cell carcinoma (OSCC) is significantly higher than that in the other patients and healthy individuals in the control group. The levels of salivary LDH in patients with SCC of the tongue and lower oral cavity were significantly higher than those in other patients affected with SCC in other parts of the head and neck (P<0.01).<br>
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<strong><em>Conclusions:</em></strong> As this enzyme increases simultaneously in both tumoral tissues and saliva, it can serve as a useful diagnostic marker for the early diagnosis and prediction of HNSCC.<br>
</div>
Biomarker, Early diagnosis, Head and neck squamous cell carcinoma (HNSCC), Lactate dehydrogenase (LDH), Saliva.
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http://rbmb.net/browse.php?a_code=A-10-142-2&slc_lang=en&sid=1
Farnaz
Mohajertehran
10031947532846006416
10031947532846006416
Yes
Dental Research Center, Mashhad University of Medical Science, Mashhad, Iran.
Hossein
Ayatollahi
10031947532846006417
10031947532846006417
No
Cancer Molecular Pathology Research Center, Department of Hematology and Blood Bank, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
Amir Hossein
Jafarian
10031947532846006418
10031947532846006418
No
Cancer Molecular Pathology Research Center, Department of Pathology, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
Kamran
Khazaeni
10031947532846006419
10031947532846006419
No
Department of Otorhinolaryngology, Mashhad University of Medical Sciences, Mashhad, Iran.
Mohammad
Soukhtanloo
10031947532846006420
10031947532846006420
No
Department of Biochemistry, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
Mohammad-Taghi
Shakeri
10031947532846006421
10031947532846006421
No
Department of Epidemiology & Biostatistics, MUMS, Mashhad, Iran.
Nooshin
Mohtasham
mohtashamn@mums.ac.ir
10031947532846006422
10031947532846006422
No
Dental Research Center, Mashhad University of Medical Science, Mashhad, Iran & Oral and Maxillofacial Disease Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.