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en Association Between IFN-γ +874 T/A (Rs2430561) Polymorphisms and Bipolar 1 Disorder: A Study in an Ethnic Iranian Population ایمنی شناسی Immunology مقالات اصلی Original Article <div style="text-align: justify;">Background: The pathophysiology of bipolar 1 disorder (B1D), a major psychiatric disorder with inflammatory origins and structural changes in the brain, is of great interest to researchers. Pro-inflammatory biomarkers and specific gene expression play pivotal roles in B1D development, and IFN-γ has emerged as an important inflammatory marker. The aim of this research was to determine whether the INF-γ +874 T/A polymorphism is associated with B1D susceptibility in an ethnic Iranian population. Methods: The IFN-γ +874 T/A (rs2430561) gene polymorphism was studied in 106 B1D patients and 109 control subjects using sequence specific primers (SSPs) and amplification refractory mutation system-polymerase chain reaction (ARMS-PCR). Results: Significant statistical differences in IFN-γ +874 T/A polymorphism genotype distribution were found between the patients and control subjects (P = 0.0006). Decreased risk of B1D was detected in the codominant model (T/T vs T/A and A/A, OR = 0.19, 95% CI = 0.07-0.49 for T/A, OR = 0.38, 95% CI = 0.12-1.24 for A/A, P value=0.0006), and in the dominant model (T/T vs T/A-A/A, OR = 0.21, 95% CI = 0.08-0.54, P = 0.0005). However, no significant difference in the IFN-γ polymorphism allele distribution was found between the two groups (P = 0.25). Conclusions: The IFN-γ +874 T/A polymorphism may have a significant role in BID development.  </div> Bipolar 1 Disorder, Gene Polymorphism, Interferon gamma 1 8 http://rbmb.net/browse.php?a_code=A-10-153-1&slc_lang=en&sid=1 Mahdieh Fatemi Nayeri fateminm932@mums.ac.ir 100319475328460017112 100319475328460017112 No Psychiatry and Behavioral Sciences Research Center, Mashhad University of Medical Sciences, Mashhad, Iran. Ali Talaei talaeia@mums.ac.ir 100319475328460017113 100319475328460017113 Yes Psychiatry and Behavioral Sciences Research Center, Mashhad University of Medical Sciences, Mashhad, Iran. Jalil Tavakkol Afshari tavakolaj@mums.ac.ir 100319475328460017114 100319475328460017114 No Immunology Research Center, Mashhad University of Medical Sciences, Mashhad, Iran. Amin Reza Nikpoor nikpoora@gmail.com 100319475328460017115 100319475328460017115 No Immunology Research Center, Mashhad University of Medical Sciences, Mashhad, Iran & Department of Immunology, Faculty of Medicine, Hormozgan University of Medical Sciences, Bandar Abbas, Iran. Andisheh Talaei talaeia@mums.ac.ir 100319475328460017116 100319475328460017116 No Department of Biotechnology, University College of Science, University of Tehran, Tehran, Iran. Rashin Ganjali ganjalir@mums.ac.ir 100319475328460017117 100319475328460017117 No Immunology Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.