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en Increased Levels of Acetylcholinesterase, Paraoxonase 1, and Copper in Patients with Moderate Depression- a Preliminary Study بیوشیمی Biochemistry مقالات اصلی Original Article <div style="text-align: justify;">Background:  Depression is a common and widespread mood disorder, which affects an emotional level that varies widely in its intensity. Biochemical parameter alterations have been observed in different depression types. In the present study, we examined acetylcholinesterase (AChE), paraoxonase 1 (PON1), and copper levels in moderately-depressed patients and healthy controls to ascertain whether the measurement of red blood cell (RBC) AChE, and plasma PON1 and copper could be used to evaluate moderate depression. Methods: This case control study was performed in the Department of Biochemistry, Kasturba Medical College, Manipal Academy of Higher Education, Manipal, Karnataka, India. Patients who met ICD 10 diagnostic criteria were considered as cases. Goldberg’s General Health Questionnaire 28 (GHQ-28) was used to select controls. Four ml of blood was collected from 24 cases and 20 controls aged 35-70 years and used to determine RBC AChE, and plasma PON1 and copper levels. Results: Red blood cell AChE, and plasma PON1 and copper levels were significantly greater in patients with moderate depression than in controls. Further, a receiver operating characteristic curve for validity of the biochemical parameters in plasma from patients with moderate depression indicated sensitivity and specificity above 85% for copper and PON1. Conclusions: Red blood cell AChE, plasma PON1, and copper levels may have roles in the pathogenesis of depressive disorders.</div> Acetylcholinesterase, Copper, Moderate Depression, PON1, Stress. 174 180 http://rbmb.net/browse.php?a_code=A-10-199-1&slc_lang=en&sid=1 Shobha Ullas Kamath shobha.kamath@manipal.edu 100319475328460017063 100319475328460017063 No Department of Biochemistry, Kasturba Medical College, Manipal Academy of Higher Education, Manipal -576104, Karnataka, India. Abhishek Chaturvedi abhishek.chaturvedi@manipal.edu 100319475328460017064 100319475328460017064 Yes Department of Biochemistry, Melaka Manipal Medical College (Manipal campus), Manipal Academy of Higher Education, Manipal -576104, Karnataka, India. Devesh Bhaskar Yerrapragada deveshyerra@gmail.com 100319475328460017065 100319475328460017065 No Department of Biochemistry, Kasturba Medical College, Manipal Academy of Higher Education, Manipal -576104, Karnataka, India. Nagendra Kundapura knagendra73@gmail.com 100319475328460017066 100319475328460017066 No Department of Biochemistry, Kasturba Medical College, Manipal Academy of Higher Education, Manipal -576104, Karnataka, India. Navaneeth Amin naviamin7@gmail.com 100319475328460017067 100319475328460017067 No Department of Biochemistry, Kasturba Medical College, Manipal Academy of Higher Education, Manipal -576104, Karnataka, India. Virupaksha Devaramane dr_viru@yahoo.com 100319475328460017068 100319475328460017068 No Department of Psychiatry, Dr. A.V. Baliga Memorial Hospital, Doddanagudde, Udupi, Karnataka, India.