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en Oxidative Stress Status and Liver Markers in Coronary Heart Disease بیوشیمی Biochemistry مقالات اصلی Original Article <div style="text-align: justify;">Background: Oxidative stress plays an important role in the development of atherosclerosis. An association exists between the alterations of liver markers and the risk of coronary heart disease (CHD). This study was designed to investigate the status of oxidative stress and liver markers in patients with CHD. Methods: This study included 50 CHD patients and 50 healthy volunteers. Serum activities of glutathione peroxidase (GPX), catalase (CAT), alkaline phosphatase (ALP), alanine aminotransferase (ALT), aspartate aminotransferase (AST), and glutathione (GSH), malondialdehyde (MDA), nitric oxide (NO), and fasting blood sugar (FBS) concentrations were measured. The Unpaired Student’s t-test was used to analyze the data. Results: Serum GSH level and CAT and GPX activities were significantly greater in healthy controls than in CHD patients. Serum MDA, NO, and FBS levels and GGT, ALT, ALP activities were significantly greater in CHD patients than in healthy controls. Serum AST activity was greater in CHD patients than in controls, but the difference was not statistically significant. Conclusions: Our results indicate that CHD is related to oxidative stress, lipid peroxidation, inflammation, and elevated liver enzyme activity. CHD is a deadly disease that requires appropriate medical care. Antioxidant treatment might inhibit disease progression.</div> Coronary heart disease, Inflammation, Liver markers, Oxidative stress 49 55 http://rbmb.net/browse.php?a_code=A-10-66-2&slc_lang=en&sid=1 Mostafa Cheraghi m.cheraghy@ymail.com 100319475328460017158 100319475328460017158 No Department of Cardiology, Madani Heart Center, Lorestan University of Medical Sciences, Khorramabad, Iran. Hassan Ahmadvand hassan_a46@yahoo.com 100319475328460017159 100319475328460017159 Yes Razi Herbal Medicine Research Center, Faculty of Medicine, Lorestan University of Medical Sciences, Khorramabad, Iran & Department of Biochemistry, Faculty of Medicine, Lorestan University of Medical Sciences, Khorramabad, Iran. Ali Maleki malehi.a@lums.ac.ir 100319475328460017160 100319475328460017160 No Department of Cardiology, Madani Heart Center, Lorestan University of Medical Sciences, Khorramabad, Iran. Esmaeel Babaeenezhad es.babaeenezhad1391@gmail.com 100319475328460017161 100319475328460017161 No Department of Clinical Biochemistry, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran. Salman Shakiba bazvand_salman@yahoo.com 100319475328460017162 100319475328460017162 No Student Research Committee, Lorestan University of Medical Sciences, Khorramabad, Iran. Fatemeh Hassanzadeh basvand_salman@yahoo.com 100319475328460017163 100319475328460017163 No Student Research Committee, Lorestan University of Medical Sciences, Khorramabad, Iran.