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en Association of Vitamin D Status with the Severity and Mortality of Community-Acquired Pneumonia in Iran during 2016-2017:A Prospective Cohort Study میکروب شناسی Microbiology مقالات اصلی Original Article <div style="text-align: justify;">Background: Community-acquired pneumonia (CAP) is a common disease considered as a major public health problem. It causes considerable morbidity and mortality despite antibiotic treatments. Hospital admission of CAP patients is a significant financial burden and many efforts are ongoing to decrease hospital stay durations. Vitamin D deficiency is associated with increased risk of respiratory infections. This study was designed to determine the association of vitamin D status with hospitalized CAP patient mortality and disease severity. Methods: This prospective cohort study examined 180 CAP patients admitted to a teaching Hospital in Tehran, Iran during 2016-2017. Their demographic and anthropometric characteristics were recorded. The disease severity was evaluated based on CURB-65. Vitamin D status was determined by measuring by serum 25-hydroxylated vitamin D (25(OH)D) with ELISA. The patients were followed for 30 days to evaluate their vitality. Results: One hundred and eighty pneumonia patients, including 104 males and 84 females, were recruited from respiratory disease, infectious disease, emergency, and ICU wards. Nearly 18% of the patients were current smokers. The CAP severity, evaluated by CURB-65, was determined to be non-severe in 74.4% of the patients. Patients were classified as vitamin D sufficient, insufficient, or deficient. Thirty percent of the patients were vitamin D sufficient, 18% were insufficient, and 52% were deficient. Thirty-day mortality was 40% (72 cases). Mortality was greater in males than in females (47.1% vs. 30.3%, p=0.03). The disease was significantly less severe in the patients who survived than in those who did not. The vitamin D status differed between males and females (p=0.027). The vitamin D status was lower in the more severe cases than in the less (p=0.036), and vitamin D deficiency was more prevalent in patients who died than in those who lived. Vitamin D concentration was negatively correlated with hospital stay duration. The 25(OH)D concentration was significantly greater in patients who survived than in those who did not (p<0.001). Conclusions: Pneumonia severity and mortality risk were greater and hospital stays longer in vitamin D-deficient patients than in those with higher vitamin D status.</div> Disease severity, Mortality, Pneumonia, Vitamin D. 85 90 http://rbmb.net/browse.php?a_code=A-10-204-1&slc_lang=en&sid=1 Fatemeh Talebi talebi.fatemeh5018@yahoo.com 100319475328460017186 100319475328460017186 No Department of Infectious Disease and Tropical Diseases, Imam Khomeini Hospital, Tehran University of Medical Sciences, Tehran, Iran. Mehrnaz Rasooli nejad rasoline@tums.ac.ir 100319475328460017187 100319475328460017187 No Professor of Infectious Diseases, Iranian Research Center for HIV/AIDS, Department of Infectious Diseases, Imam Khomeini hospital, Tehran University of Medical Sciences, Tehran, Iran. Mehdi Yaseri myaseri@sina.tums.ac.ir 100319475328460017188 100319475328460017188 No Department of Epidemiology and Biostatistics, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran. Azar Hadadi hadadiaz@tums.ac.ir 100319475328460017189 100319475328460017189 Yes Professor of Infectious Diseases, Research Development Center, Sina hospital, Tehran University of Medical Sciences, Tehran, Iran.