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en Comparison of Serum Levels of Fructosamine and Erythrocyte Sodium Potassium ATPase (Na+/K+ ATPase) in Gestational Diabetes Mellitus (GDM) and non-Gestational Diabetes Mellitus (non GDM) Patients بیوشیمی Biochemistry مقالات اصلی Original Article <div style="text-align: justify;">Background: The study aims at the comparison and correlation of serum levels of fructosamine and erythrocyte Na+/ K+ ATPase in Gestational diabetes mellitus (GDM) and Non Gestational Diabetes Mellitus (Non GDM). Methods: A total of 326 samples were divided into 4 groups. Pregnant women between the age group of 20-40 years who gave samples for Oral Glucose Tolerance Test (OGTT) were included as the subjects. Anonymized and left over fasting and 2 hours’ samples were collected from biochemistry laboratory, Kasturba Hospital, Manipal. Results: In the comparison of fructosamine levels in GDM and Non GDM, fructosamine was found to be significant (p value<0.001) in both fasting and 2 hours (G2) blood glucose condition. Na+/ K+ ATPase did not show any significant variation between the groups. Correlation was not significant between the parameters. Conclusions: Fructosamine showed significant increase when compared between the groups, whereas significant correlation is not obtained between the parameters. Thus, the use fructosamine as a diagnosis tool becomes inconclusive. Further studies must be carried out to identify a marker which reduces the interferences observed in fructosamine and to find out the exact relationship between hyperglycaemia and Na+/ K+ ATPase activity.</div> Fructosamine, Gestational Diabetes Mellitus, Na+/ K+ Atpase Enzyme Activity, Screening Test 253 259 http://rbmb.net/browse.php?a_code=A-10-270-1&slc_lang=en&sid=1 Revathi Panduranga Shenoy revathi.shenoy@manipal.edu 100319475328460017350 100319475328460017350 No Department of Biochemistry, Kasturba Medical College Manipal, Manipal Academy of Higher Education Manipal, Karnataka, India. Gagana Hanumaiah 100319475328460017351 100319475328460017351 No Department of Biochemistry, Kasturba Medical College Manipal, Manipal Academy of Higher Education Manipal, Karnataka, India. Varashree Bolar Suryakanth varashree.bs@manipal.edu 100319475328460017352 100319475328460017352 Yes Department of Biochemistry, Kasturba Medical College Manipal, Manipal Academy of Higher Education Manipal, Karnataka, India. Priyanka Shridharan m.priyankasree@gmail.com 100319475328460017353 100319475328460017353 No Department of Biochemistry, Kasturba Medical College Manipal, Manipal Academy of Higher Education Manipal, Karnataka, India.