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en Pattern of ABCC Transporter Gene Expression in Pediatric Patients with Relapsed Acute Lymphoblastic Leukemia زیست شناسی ملکولی Molecular Biology مقالات اصلی Original Article <div style="text-align: justify;">Background: Abnormal expression of ABCC transporter genes has been associated with treatment failure in pediatric patients with acute lymphoblastic leukemia (ALL). The aim of this study was to evaluate the expression pattern of ABCC1-6 and ABCC10 genes in Iranian pediatric patients with ALL relapse and determine the potential predictive value of determining ALL relapse from ABCC expression. Methods: Patients with ALL were divided into two separate groups, either the case group with relapsed ALL or the control group in which ALL patients have been in progression-free survival for at least 3 years A total of thirty-nine participants (23 with relapsed ALL; 16 controls) were enrolled over 26 months. To determine the levels of ABCC1-6 and ABCC10 transporter gene expression RT-PCR was used. Cumulative doses of the chemotherapy drugs, VCR, DNR and L-ASP, were calculated for each patient. Results: Our findings showed elevated expression of ABCC2-6 and decreased expression of ABCC1 and ABCC10 to be associated with an increased risk of ALL relapse. The mean-fold expression of ABCC2 was significantly increased in the ALL relapse group. Additionally, the expression pattern of the ABCC transporter genes was associated with high doses of three chemotherapy drugs, VCR, DNR and L-ASP. Conclusions: Evaluating the expression pattern of ABCC transporter genes may be a potential biomarker for predicting the occurrence of ALL relapse in Iranian pediatric patients and improve cancer prognosis.  </div> ABC transporters, ‍Childhood, Gene expression, Pattern, Recurrence. 184 193 http://rbmb.net/browse.php?a_code=A-10-315-1&slc_lang=en&sid=1 Narjes Mehrvar narjes.mehrvar@gmail.com 100319475328460017284 100319475328460017284 No Cancer Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran. Hassan Abolghasemi pchd1391@gmail.com 100319475328460017285 100319475328460017285 No Pediatric Congenital Hematologic Disorders Research Center, Research Institute for Children's Health, Shahid Beheshti University of Medical Sciences, Tehran, Iran. Mohammad Reza Rezvany mohrezrez@yahoo.com 100319475328460017286 100319475328460017286 No Hematology department, Faculty of Allied Medicine, Iran University of Medical Sciences, Tehran, Iran. & Department of Oncology-Pathology, Immune and Gene Therapy Lab, Cancer Center Karolinska (CCK), Karolinska University Hospital Solna and Karolinska Institutet, Stockholm, Sweden. Mohammad Esmaeil Akbari crccbils@gmail.com 100319475328460017287 100319475328460017287 No Cancer Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran. Javad Saberynejad javad.saberynejad@gmail.com 100319475328460017288 100319475328460017288 No AJA University of Medical Sciences, Tehran, Iran. Azim Mehrvar drazimmehrvar@yahoo.com 100319475328460017289 100319475328460017289 No AJA University of Medical Sciences, Tehran, Iran. & Mahak Hematology Oncology Research Center (Mahak-HORC), Mahak Hospital, Tehran, Iran. Mohammad Ali Ehsani maehsani@gmail.com 100319475328460017290 100319475328460017290 No Bahrami Hospital, Tehran University of Medical Sciences, Tehran, Iran. Mahyar Nourian mahyarnourian1369@gmail.com 100319475328460017291 100319475328460017291 No Mahak Hematology Oncology Research Center (Mahak-HORC), Mahak Hospital, Tehran, Iran. Ibrahim Qaddoumi ibrahim.qaddoumi@stjude.org 100319475328460017292 100319475328460017292 No Department of Global Pediatric Medicine, St. Jude Children’s Research Hospital, Memphis, TN USA. Abolfazl Movafagh movafagh_a@yahoo.com 100319475328460017293 100319475328460017293 Yes Cancer Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran. & Department of Medical Genetics, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran