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en Introducing the Best Six Loci in Mycobacterial Interspersed Repetitive Unit-Variable-Number Tandem Repeat (MIRU-VNTR) Typing for Mycobacterium TuberculosisGenotyping میکروب شناسی Microbiology مقالات مروری Review <div style="text-align: justify;">Background: Tuberculosis (TB) still remains endemic worldwide making epidemiological studies essential to mitigating efforts implicated in identifying its source,controlling, and preventing the spread of dangerous strains amongst humans such as Mycobacterium tuberculosis (Mtb). Methods: In this study, we sought to determine the 6 Mycobacterial Interspersed Repetitive Unit-Variable-Number Tandem Repeat (MIRU-VNTR) loci with high discriminatory powers for Mtb genotypingas well as the loci with the highest and the lowest discriminatory powers for MIRU-VNTR.To conduct our search, we used several databases such as science direct, Embase (Elsevier), Web of Science, Scopus and Medline via PubMed. Searches were performed using key words including: Mycobacterium tuberculosis, MIRU–VNTR, Allele diversity, Genetic diversity and human patient. Finally, 56 articles were selected after filtering out titles, abstracts and full texts. Results: Loci with high discriminatory powers included MIRU10 and MIRU26, while MIRU2, MIRU20, MIRU24 and ETRD had poor discriminatory powers. According to previous data in the literature, the loci MIRU10, MIRU26, MIRU40, QUB 26, QUB 11b and Mtub21 have high discriminatory powers. Conclusions:Therefore, these loci recommended for genotyping Mtb to save time and cost and to ensure the production of reliable results.</div> Discriminatory power, Genotyping, MIRU-VNTR, Mycobacterium tuberculosis 335 346 http://rbmb.net/browse.php?a_code=A-10-201-1&slc_lang=en&sid=1 Mahdis Ghavidel 100319475328460017384 100319475328460017384 Yes Antimicrobial Resistance Research Center, Mashhad University of Medical Sciences, Mashhad, Iran. & Department of Microbiology and Virology, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran. Keyvan Tadayon 100319475328460017385 100319475328460017385 No Department of Microbiology, Razi Vaccine and Serum Research Institute (RVSRI), Agricultural Research, Education and ExtensionOrganization (AREEO), Karaj, Iran Nader Mosavari 100319475328460017386 100319475328460017386 No PPD Tuberculin Department, Razi Vaccine and Serum Research Institute, (RVSRI), Agricultural Research, Education and Extension Organization (AREEO), Karaj, Iran. Kimiya Nourian 100319475328460017387 100319475328460017387 No Doctor of Veterinary Medicine, Graduate Student of School of Veterinary Medicine, Ferdowsi University of Mashhad, Mashhad,Iran. Hamid Reza BahramiTaghanaki 100319475328460017388 100319475328460017388 No School of Persian Medicine, Mashhad University of Medical Sciences, Mashhad, Iran Gholam Reza Mohammadi 100319475328460017389 100319475328460017389 No Department of Clinical Sciences, School of Veterinary Medicine, Ferdowsi University of Mashhad, Mashhad –Iran. Mohammad Rashtibaf 100319475328460017390 100319475328460017390 No Deputy of Veterinary administration of Khorasan Razavi Province, Mashhad,Iran. Kiarash Ghazvini Ghazvinik@mums.ac.ir 100319475328460017391 100319475328460017391 No Antimicrobial Resistance Research Center, Mashhad University of Medical Sciences, Mashhad, Iran. & Department of Microbiology and Virology, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.