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en Antiproliferative Activity of Hypericum perforatum, Achillea millefolium, and Aloe vera in Interaction with the Prostatic Activity of CD82 زیست شناسی سلولی Cell Biology مقالات اصلی Original Article <div style="text-align: justify;">Background: In recent years, prostate cancer prevails as one of the lead cancers affecting men. Currently, prostate cancer research involves the phytochemical study of plants with anti-tumour effects. This study compares the anti-tumour effects of three plant species indigenous to Iran and their interaction with cluster of differentiation (CD)-82 protein, a therapeutic target found in prostate cancer cells. Methods: The extracts of Hypericum perforatum, Achillea millefolium, and Aloe vera were prepared and their toxicological, cellular and gene expression responses were evaluated in PC-3 human prostate cancer cells and normal human chondrocyte cell line C28/I2. They were exposed to different concentrations of the plants (10 mg/mL, 5 mg/mL, 1 mg/mL, 100 µg/mL, 10 µg/mL, and 1 µg/mL) at three exposure time points (24, 48, 72 hours) to determine cancer cell cytotoxicity and gene expression profiles. Results: Half-maximal inhibitory concentration (IC50) in PC-3 cells ranged from 0.6 to 8.5 mg/mL for H. perforatum extract, from 0.4 to 7.5 mg/mL for A. Millefolium extract, and from 0.2 to 8.0 mg/mL for A. vera extract in a time-dependent manner. A. vera extract caused the highest cell death levels in PC-3 cells (94%) and C28/I2 cells (57%) after 48 hours. A 1.97-, 3.00-, and 3.48-fold increase in relative gene expression of CD82 was observed for H. perforatum, A. millefolium, and A. vera extracts, respectively Conclusions: A. vera and A. millefolium extracts are a selective inhibitor of prostate cancer cells and a potent activator of CD82 expression.  </div> CD82, Gene expression, Herbal medicine, Prostate cancer. 260 268 http://rbmb.net/browse.php?a_code=A-10-320-1&slc_lang=en&sid=1 Motahare-Sadat Hosseini hosseini181@gmail.com 100319475328460017354 100319475328460017354 No Department of Biomedical Engineering, Amirkabir University of Technology, Tehran, Iran. Fatemehsadat Hosseini hosseinif6838@gmail.com 100319475328460017355 100319475328460017355 No Faculty of Paramedical Sciences, Mashhad University of Medical Sciences, Mashhad, Iran. Abdolreza Ahmadi aa_13651363@yahoo.com 100319475328460017356 100319475328460017356 No Faculty of Paramedical Sciences, Mashhad University of Medical Sciences, Mashhad, Iran. Masoud Mozafari mozafari.masoud@gmail.com 100319475328460017357 100319475328460017357 No Cellular and Molecular Research Center, Iran University of Medical Sciences, Tehran, Iran. Issa Amjadi gc0645@wayne.edu 100319475328460017358 100319475328460017358 Yes Department of Biomedical Engineering, Wayne State University, Detroit, MI, United States.