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en Increased mRNA Expression of CTRP3 and CTRP9 in Adipose Tissue from Obese Women: Is it Linked to Obesity-Related Parameters and mRNA Expression of Inflammatory Cytokines? بیوشیمی Biochemistry مقالات اصلی Original Article <div style="text-align: justify;">Background: Obesity, a medical condition with impaired adipokine secretion and function, has a detrimental effect on insulin and glucose metabolism. CTRP3 and CTRP9 are adipokines with possible roles in energy homeostasis regulation. We sought to compare CTRP3, CTRP9, and inflammatory gene expression in subcutaneous adipose tissue (SAT) and visceral adipose tissue (VAT) from obese women who underwent bariatric surgery and non-obese women as controls. Methods: For this study, the investigators recruited 20 morbidly obese women (BMI> 35) who qualified for bariatric surgery and 20 normal-weight women (BMI< 25) who underwent elective surgeries. Real-time PCR was performed to investigate mRNA expression of CTRP3, CTRP9, and the inflammatory genes IL1-β, IL-6, MCP-1, and TNF-α in SAT and VAT from both obese patients and controls. Results: We observed that CTRP3 mRNA levels were significantly greater in VAT from obese patients than from controls (P< 0.0003). Also, patient group had higher levels of CTRP9 that control group (P< 0.0026). Inflammatory cytokines were markedly increased in SAT of obese patients compared to controls (P< 0.05). In addition, our results revealed a positive correlation of CTRP9 with HOMA-IR and waist circumference in VAT and CTRP3 with IL-1β, MCP-1, and TNF-α in SAT. Conclusions: Both CTRP3 and CTRP9 expression were significantly higher in VAT from obese patients than from controls, and CTRP3 expression positively correlated with inflammatory parameters. Our findings indicate that CTRP3 and CTRP9 might be important in regulating glucose metabolism and obesity-related conditions such as inflammation.</div> Adipokine, CTRP3, CTRP9, Obesity, Obese women. 71 81 http://rbmb.net/browse.php?a_code=A-10-399-1&slc_lang=en&sid=1 Seyed Mohammad Masoodian m.masoodian@sbmu.ac.ir 100319475328460017529 100319475328460017529 No Department of Medical Laboratory Sciences, School of Allied Medical Sciences, Student Research Committee, Shahid Beheshti University of Medical Sciences, Tehran, Iran. Karamollah Toolabi Tolabika@tums.ac.ir 100319475328460017530 100319475328460017530 No Department Surgery, Imam Khomeini Hospital, Tehran University of Medical Sciences, Tehran, Iran. Abolfazl Omidifar 100319475328460017531 100319475328460017531 No Department of Medical Laboratory Sciences, School of Allied Medical Sciences, Student Research Committee, Shahid Beheshti University of Medical Sciences, Tehran, Iran. Hossein Zabihi 100319475328460017532 100319475328460017532 No Sina Hospital, Department of Surgery, school of medicine, Tehran University of Medical Sciences, Tehran, Iran. Ali Rahimipour a.rahimipour@sbmu.ac.ir 100319475328460017533 100319475328460017533 No Department of Clinical Biochemistry, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran. & Department of Medical Laboratory Sciences, School of Allied Medical Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran. Mehrnoosh Shanaki shanaki_m@sbmu.ac.ir 100319475328460017534 100319475328460017534 Yes Department of Clinical Biochemistry, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.