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Reports of Biochemistry and Molecular Biology
rbmb.net
Basic Sciences
http://rbmb.net
1
admin
2322-3480
2322-3480
10.61882/rbmb
en
jalali
1399
3
1
gregorian
2020
6
1
9
2
online
1
fulltext
en
Protective Effect of Oxytocin Against Bone Loss in a Female Rat Model of Osteoporosis
زیست شناسی سلولی
Cell Biology
مقالات اصلی
Original Article
<div style="text-align: justify;"><strong><em>Background:</em></strong> Introduction: Oxytocin (OT) has been proposed to assist in the regulation of bone remodeling and to exert an antiosteoporotic effect. We evaluated the possible protective effect of OT against bone degeneration in ovariectomized (OVX) rats.<br>
<br>
<strong><em>Methods:</em></strong> The study was performed on three groups of adult female rats; group I was subjected to sham operation, group II was subjected to ovariectomy, and group III was subjected to ovariectomy and intraperitoneal injection with OT for eight successive weeks. At the end of the study, bone mass density (BMD) was measured; then the rats were euthanized and their blood and bone tissues were examined.<br>
<br>
<strong><em>Results:</em></strong> The group II rats had significantly less BMD and greater serum bone-specific alkaline phosphatase (bALP), osteocalcin (OC), and tartrate-resistant acid phosphatase (TRAP) levels than the group I rats. Furthermore, group II rats had fewer osteocytes and osteoblasts, and less OPG/RANKL mRNA expression than group I rats. The groups I and III and rats showed no significant differences in BMD, bALP, OC, TRAP, OPG/RANKL mRNA expression, or osteocyte and osteoblast numbers.<br>
<br>
<strong><em>Conclusions:</em></strong> Oxytocin may have an antiosteoporotic effect in OVX rats.</div>
Osteoporosis, OPG, Oxytocin, Ovariectomy, RANKLKL
147
155
http://rbmb.net/browse.php?a_code=A-10-469-1&slc_lang=en&sid=1
Hoda
Moghazy
100319475328460017570
100319475328460017570
No
Medical Physiology Department, Faculty of Medicine, Sohag University, Egypt
Aida
Mahmoud
aidamahmoud11@yahoo.com
100319475328460017571
100319475328460017571
Yes
Medical Biochemistry Department, Faculty of Medicine, Sohag University, Egypt
Hala
ElBadre
100319475328460017572
100319475328460017572
No
Medical Biochemistry Department, Faculty of Medicine, Assiut University, Egypt
Hekmat Osman
Abdel Aziz
100319475328460017573
100319475328460017573
No
Histology Departments, Faculty of Medicine, Sohag University, Egypt